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    Gbp3 Growth-blocking peptide 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gbp3provided by FlyBase
    Official Full Name
    Growth-blocking peptide 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039031
    Locus tag
    Dmel_CG17244
    See related
    AllianceGenome:FB:FBgn0039031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH17470; CG17244; Dmel\CG17244; GBP; GBP3
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Is expressed in adult fat body; adult head; and embryonic/larval fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gbp3 in Genome Data Viewer
    Location:
    94D6-94D6; 3-77 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22977270..22978164)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18802992..18803886)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43655 Neighboring gene Transition protein-like 94D Neighboring gene Na[+]/H[+] hydrogen antiporter 2 Neighboring gene Odorant receptor 94a Neighboring gene Odorant receptor 94b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. Koyama T, et al. PLoS Biol, 2016 Feb. PMID 26928023, Free PMC Article
    2. Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection. O'Connor JT, et al. Dev Cell, 2021 Aug 9. PMID 34273275, Free PMC Article
    3. Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. Tsuzuki S, et al. Sci Rep, 2012. PMID 22355724, Free PMC Article
    4. Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster. Rollmann SM, et al. Nat Genet, 2006 Jul. PMID 16783380
    5. Interorgan communication in development and cancer. Alvarez-Ochoa E, et al. Wiley Interdiscip Rev Dev Biol, 2021 Jul. PMID 32852143

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Growth-blocking peptide 3
    Names
    CG17244-PA
    CG17244-PB
    Gbp3-PA
    Gbp3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22977270..22978164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300548.1 → NP_001287477.1  Growth-blocking peptide 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCT2

    2. NM_142848.3 → NP_651105.1  Growth-blocking peptide 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCT2
      Related
      FBpp0083733
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCT2 Q9VCT2

    Gene LinkOut

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