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    Hat1 Histone acetyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hat1provided by FlyBase
    Official Full Name
    Histone acetyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037376
    Locus tag
    Dmel_CG2051
    See related
    AllianceGenome:FB:FBgn0037376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2051; Dmel\CG2051; dmHAG409; HAT1
    Summary
    Enables histone H4 acetyltransferase activity. Involved in CENP-A containing chromatin assembly. Predicted to be located in nucleus. Is expressed in dorsal epidermis primordium; embryonic dorsal epidermis; embryonic ventral epidermis; gut section; and ventral epidermis primordium. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hat1 in Genome Data Viewer
    Location:
    83C4-83C4; 3-47.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5787337..5789384, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1613059..1615106, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 8 Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene katanin p60-like 1 Neighboring gene Regulatory particle non-ATPase 5 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hat1 acetylates histone H4 and modulates the transcriptional program in Drosophila embryogenesis. Varga J, et al. Sci Rep, 2019 Nov 29. PMID 31784689, Free PMC Article
    2. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. Stewart A, et al. J Neurosci, 2012 Aug 22. PMID 22915107, Free PMC Article
    3. Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging. Hunt LC, et al. Nat Commun, 2021 Mar 3. PMID 33658508, Free PMC Article
    4. SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3' end processing. Yu S, et al. Nucleic Acids Res, 2018 Sep 19. PMID 29860334, Free PMC Article
    5. A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster. Boltengagen M, et al. Nucleic Acids Res, 2016 Mar 18. PMID 26586808, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hat1 acetylates histone H4 and modulates the transcriptional program in Drosophila embryogenesis.
      Title: Hat1 acetylates histone H4 and modulates the transcriptional program in Drosophila embryogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase 1
    Names
    CG2051-PA
    CG2051-PB
    Hat1-PA
    Hat1-PB
    NP_649587.1
    NP_731006.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5787337..5789384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169106.2 → NP_731006.1  histone acetyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIB3, Q4QQC4
      Related
      FBpp0078318
      Conserved Domains (2) summary
      pfam10394
      Location:10 → 173
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
      pfam11221
      Location:368 → 403
      Med21; Subunit 21 of Mediator complex

    2. NM_141330.2 → NP_649587.1  histone acetyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIB3, Q4QQC4
      Related
      FBpp0078319
      Conserved Domains (2) summary
      pfam10394
      Location:10 → 173
      Hat1_N; Histone acetyl transferase HAT1 N-terminus
      pfam11221
      Location:368 → 403
      Med21; Subunit 21 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KIB3 Q0KIB3

    Gene LinkOut

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