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    QIL1 QIL1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    QIL1provided by FlyBase
    Official Full Name
    QIL1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036726
    Locus tag
    Dmel_CG7603
    See related
    AllianceGenome:FB:FBgn0036726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7603; Dmel\CG7603; MIC13
    Summary
    Involved in cristae formation and regulation of cristae formation. Part of MICOS complex. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 37. Orthologous to human MICOS13 (mitochondrial contact site and cristae organizing system subunit 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See QIL1 in Genome Data Viewer
    Location:
    74C3-74C3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17465945..17466768)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17459045..17459868)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44565 Neighboring gene Secretory chloride channel Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase ubiquinone-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue. Wang LJ, et al. Biol Open, 2020 Dec 2. PMID 33268479, Free PMC Article
    2. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article
    3. Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity. Birker K, et al. Elife, 2023 Jul 5. PMID 37404133, Free PMC Article
    4. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article
    5. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Huynen MA, et al. Biochim Biophys Acta, 2016 Jan. PMID 26477565

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MICOS complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    is_active_in mitochondrial crista junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    QIL1
    Names
    CG7603-PA
    QIL1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17465945..17466768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140726.3 → NP_648983.1  QIL1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVH3
      UniProtKB/TrEMBL
      A0A1B2AJ92
      Related
      FBpp0074982
      Conserved Domains (1) summary
      pfam15884
      Location:3 → 97
      QIL1; Protein QIL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVH3.1 Q9VVH3

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