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    l(3)73Ah lethal (3) 73Ah [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)73Ahprovided by FlyBase
    Official Full Name
    lethal (3) 73Ahprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002283
    Locus tag
    Dmel_CG4195
    See related
    AllianceGenome:FB:FBgn0002283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4195; Dmel\CG4195; I(3)73Ah; l(3)02540; l(3)133.18; L(3)73Ah
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in fat body; organism; and ovary. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)73Ah in Genome Data Viewer
    Location:
    73A10-73A10; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16588475..16590132)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16581575..16583232)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ubiquinol-cytochrome c reductase core protein 2 Neighboring gene antisense RNA:CR45895 Neighboring gene Syntaxin 8 Neighboring gene uncharacterized protein Neighboring gene transformer Neighboring gene spindle defective 2 Neighboring gene Apollo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetics of transformer, a genetic switch controlling sexual differentiation in Drosophila. Belote JM, et al. Dev Genet, 1989. PMID 2472240
    2. Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains. Emmons RB, et al. Genetics, 2009 Aug. PMID 19528329, Free PMC Article
    3. The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. Irminger-Finger I, et al. Gene, 1995 Oct 3. PMID 7590267
    4. Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence. O'Neil MT, et al. Genetics, 1992 May. PMID 1592233, Free PMC Article
    5. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Gertler FB, et al. Cell, 1989 Jul 14. PMID 2502313

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) 73Ah
    Names
    CG4195-PA
    CG4195-PB
    l(3)73Ah-PA
    l(3)73Ah-PB
    lethal(3)73Ah

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16588475..16590132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080194.4 → NP_524933.1  lethal (3) 73Ah, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV77
      Related
      FBpp0075071
      Conserved Domains (2) summary
      cd16735
      Location:13 → 59
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:133 → 217
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    2. NM_001259868.2 → NP_001246797.1  lethal (3) 73Ah, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV77
      Conserved Domains (2) summary
      cd16735
      Location:13 → 59
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:133 → 217
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV77 Q9VV77

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