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    Dscam4 Down syndrome cell adhesion molecule 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2769008, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dscam4provided by FlyBase
    Official Full Name
    Down syndrome cell adhesion molecule 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0263219
    Locus tag
    Dmel_CG42330
    See related
    AllianceGenome:FB:FBgn0263219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13672; CG18630; CG33274; CG42330; CG7060; CT21829; Dmel\CG42330; DSCAM
    Old locus tag
    CG13672; Dmel_CG13672; Dmel_CG33274
    Summary
    Predicted to enable cell-cell adhesion mediator activity and identical protein binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and nervous system development. Predicted to be active in axon and plasma membrane. Is expressed in adult head. Orthologous to human DSCAM (DS cell adhesion molecule) and DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dscam4 in Genome Data Viewer
    Location:
    66C1-66C4; 3-24 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8238647..8282398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8231747..8275498)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43953 Neighboring gene eukaryotic translation initiation factor 4E3 Neighboring gene uncharacterized protein Neighboring gene ceramide transfer protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity  
    enables identical protein binding  
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in cell adhesion  
    involved_in central nervous system development  
    involved_in dendrite self-avoidance  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    Component Evidence Code Pubs
    is_active_in axon  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    down syndrome cell adhesion molecule 4
    Names
    CG42330-PD
    CG42330-PE
    CG42330-PH
    CG42330-PI
    CG42330-PJ
    Dscam4-PD
    Dscam4-PE
    Dscam4-PH
    Dscam4-PI
    Dscam4-PJ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8238647..8282398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144436.2 → NP_001137908.1  down syndrome cell adhesion molecule 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G9
      Conserved Domains (8) summary
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain
    2. NM_001274642.1 → NP_001261571.1  down syndrome cell adhesion molecule 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHS6
      Conserved Domains (8) summary
      cd00063
      Location:906 → 999
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1117 → 1203
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain
    3. NM_001144437.2 → NP_001137909.1  down syndrome cell adhesion molecule 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0D9
      Conserved Domains (8) summary
      cd00096
      Location:439 → 513
      Ig; Immunoglobulin domain
      smart00408
      Location:532 → 594
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:624 → 703
      IG; Immunoglobulin
      smart00410
      Location:429 → 516
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:335 → 416
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cl11960
      Location:819 → 909
      Ig; Immunoglobulin domain
    4. NM_001274643.2 → NP_001261572.1  down syndrome cell adhesion molecule 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHS6
      Conserved Domains (8) summary
      cd00063
      Location:906 → 999
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1117 → 1203
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain
    5. NM_001043131.3 → NP_001036596.2  down syndrome cell adhesion molecule 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036596.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G9
      Conserved Domains (8) summary
      cd00063
      Location:906 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1123 → 1209
      fn3; Fibronectin type III domain
      cd00096
      Location:611 → 613
      Ig; Ig strand A [structural motif]
      cd20954
      Location:706 → 801
      IgI_7_Dscam; Seventh immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20956
      Location:422 → 516
      IgI_4_Dscam; Fourth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cd20957
      Location:329 → 417
      IgC2_3_Dscam; Third immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the Constant 2 (C2)-set of IgSF domains
      cd20958
      Location:520 → 607
      IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:610 → 703
      Ig; Immunoglobulin domain
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