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    Larp4B La-related protein 4B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Larp4Bprovided by FlyBase
    Official Full Name
    La-related protein 4Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035424
    Locus tag
    Dmel_CG11505
    See related
    AllianceGenome:FB:FBgn0035424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11505; Dmel\CG11505; larp4B
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in negative regulation of cell growth and negative regulation of translation. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in adult head. Orthologous to several human genes including LARP4 (La ribonucleoprotein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Larp4B in Genome Data Viewer
    Location:
    63C1-63C1; 3-7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3224838..3236604)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3224838..3236604)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L28 Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    La-related protein 4B
    Names
    CG11505-PA
    CG11505-PB
    CG11505-PD
    Larp4B-PA
    Larp4B-PB
    Larp4B-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3224838..3236604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206263.4 → NP_995985.2  La-related protein 4B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995985.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7T7
      UniProtKB/TrEMBL
      A0A0H4YFU3
      Conserved Domains (2) summary
      cd08031
      Location:259 → 333
      LARP_4_5_like; La RNA-binding domain of proteins similar to La-related proteins 4 and 5
      cd12430
      Location:338 → 413
      RRM_LARP4_5_like; RNA recognition motif (RRM) found in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins

    2. NM_168007.2 → NP_728843.1  La-related protein 4B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7T7
      UniProtKB/TrEMBL
      A0A0H4YFU3
      Related
      FBpp0072909
      Conserved Domains (2) summary
      cd08031
      Location:259 → 333
      LARP_4_5_like; La RNA-binding domain of proteins similar to La-related proteins 4 and 5
      cd12430
      Location:338 → 413
      RRM_LARP4_5_like; RNA recognition motif (RRM) found in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins

    3. NM_139536.4 → NP_647793.1  La-related protein 4B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647793.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0H4YFU3, Q7KV72, Q7YTX9, Q9I7T7, Q9VZS2
      Related
      FBpp0072910
      Conserved Domains (2) summary
      cd08031
      Location:269 → 343
      LARP_4_5_like; La RNA-binding domain of proteins similar to La-related proteins 4 and 5
      cd12430
      Location:348 → 423
      RRM_LARP4_5_like; RNA recognition motif in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7T7.2 Q9I7T7

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