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    RabX1 RabX1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44172, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RabX1provided by FlyBase
    Official Full Name
    RabX1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015372
    Locus tag
    Dmel_CG3870
    See related
    AllianceGenome:FB:FBgn0015372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF47018; CG3870; chr; chrw; Chrw; Dmel\CG3870; DmRabX1; l(2)k06908; Rab31; RAB5c; rabX1
    Summary
    Predicted to enable GTPase activity. Involved in endosome membrane tubulation and positive regulation of protein catabolic process. Located in late endosome. Is expressed in several structures, including Bolwig organ; brain; imaginal disc; mushroom body; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RabX1 in Genome Data Viewer
    Location:
    59E2-59E2; 2-103 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23519839..23523613, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19407362..19411136, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43794 Neighboring gene uncharacterized protein Neighboring gene minus Neighboring gene brown Neighboring gene pickpocket 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability. Graham LC, et al. Cells, 2021 Dec 2. PMID 34943911, Free PMC Article
    2. Interplay of developmentally regulated gene expression and heterochromatic silencing in trans in Drosophila. Sage BT, et al. Genetics, 2008 Feb. PMID 18245337, Free PMC Article
    3. Three mechanisms control E-cadherin localization to the zonula adherens. Woichansky I, et al. Nat Commun, 2016 Mar 10. PMID 26960923, Free PMC Article
    4. Differential gene silencing by trans-heterochromatin in Drosophila melanogaster. Csink AK, et al. Genetics, 2002 Jan. PMID 11805061, Free PMC Article
    5. RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism. Laiouar S, et al. Curr Biol, 2020 Apr 6. PMID 32059769

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome HDA PubMed 
    located_in synapse HDA PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RabX1
    Names
    CG3870-PA
    RabX1-PA
    chrowded

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23519839..23523613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079974.3 → NP_524713.1  RabX1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3C2
      Related
      FBpp0072029
      Conserved Domains (2) summary
      cd00154
      Location:7 → 166
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      pfam00071
      Location:7 → 166
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3C2 Q9V3C2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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