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    Gpxl Glutathione peroxidase-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpxlprovided by FlyBase
    Official Full Name
    Glutathione peroxidase-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034415
    Locus tag
    Dmel_CG15116
    See related
    AllianceGenome:FB:FBgn0034415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15116; Dmel\CG15116; GPx-like
    Summary
    Predicted to enable thioredoxin-dependent peroxiredoxin activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpxl in Genome Data Viewer
    Location:
    56B2-56B2; 2-88 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19055231..19055924, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14942736..14943429, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1A Neighboring gene Ionotropic receptor 56a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative glutathione peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Missirlis F, et al. Biol Chem, 2003 Mar. PMID 12715897
    2. Exposure to endosulfan influences sperm competition in Drosophila melanogaster. Misra S, et al. Sci Rep, 2014 Dec 11. PMID 25503806, Free PMC Article
    3. Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development. Huang W, et al. Dev Biol, 2022 Oct. PMID 35853502, Free PMC Article
    4. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. Moskalev A, et al. BMC Genomics, 2015. PMID 26694630, Free PMC Article
    5. Transcriptomic analysis of the life-extending effect exerted by black rice anthocyanin extract in D. melanogaster through regulation of aging pathways. Li X, et al. Exp Gerontol, 2019 May. PMID 30682390

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-dependent peroxiredoxin activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    glutathione peroxidase-like
    Names
    CG15116-PA
    Gpxl-PA
    NP_611393.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19055231..19055924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137549.2 → NP_611393.2  glutathione peroxidase-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611393.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6H2
      Conserved Domains (1) summary
      cd00340
      Location:39 → 187
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V6H2 Q4V6H2

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