U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SCCRO3 Squamous cell carcinoma-related oncogene 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36426, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SCCRO3provided by FlyBase
    Official Full Name
    Squamous cell carcinoma-related oncogene 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033784
    Locus tag
    Dmel_CG13322
    See related
    AllianceGenome:FB:FBgn0033784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.137; CG13322; Dmel\CG13322; dSCCRO3
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Involved in positive regulation of protein neddylation. Located in plasma membrane. Is expressed in adult head. Orthologous to human DCUN1D3 (defective in cullin neddylation 1 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SCCRO3 in Genome Data Viewer
    Location:
    49E1-49E1; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12934234..12936535, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8821739..8824040, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sugarbabe Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Scaffold protein containing ankyrin repeats and SAM domain Neighboring gene Multi drug resistance 49

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation. Fu W, et al. J Biol Chem, 2016 Mar 18. PMID 26792857, Free PMC Article
    2. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
    3. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
    4. Transcriptional Correlates of Chronic Alcohol Neuroadaptation in Drosophila Larvae. Anqueira-González A, et al. Front Behav Neurosci, 2021. PMID 34803626, Free PMC Article
    5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein neddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    squamous cell carcinoma-related oncogene 3
    Names
    CG13322-PA
    CG13322-PB
    CG13322-PC
    SCCRO3-PA
    SCCRO3-PB
    SCCRO3-PC
    squamous cell carcinoma-related oncogene 3 ortholog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12934234..12936535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136984.4 → NP_610828.2  squamous cell carcinoma-related oncogene 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610828.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8S1, Q9V6I4
      Related
      FBpp0086918
      Conserved Domains (1) summary
      pfam03556
      Location:180 → 299
      Cullin_binding; Cullin binding

    2. NM_165962.4 → NP_725243.1  squamous cell carcinoma-related oncogene 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725243.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8S1, Q9V6I4
      Related
      FBpp0086917
      Conserved Domains (1) summary
      pfam03556
      Location:180 → 299
      Cullin_binding; Cullin binding

    3. NM_165963.3 → NP_725244.1  squamous cell carcinoma-related oncogene 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8S1, Q9V6I4
      Related
      FBpp0086916
      Conserved Domains (1) summary
      pfam03556
      Location:180 → 299
      Cullin_binding; Cullin binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8S1 Q8T8S1
    Q8T8S1.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous