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    CG13185 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13185provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033661
    Locus tag
    Dmel_CG13185
    See related
    AllianceGenome:FB:FBgn0033661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18329; Dmel\CG13185
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in ribosomal large subunit assembly and ribosomal large subunit export from nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleus. Is expressed in several structures, including adult fat body; embryonic/larval midgut primordium; larval muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human MDN1 (midasin AAA ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13185 in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11867876..11885585, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7755381..7773090, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Death associated molecule related to Mch2 caspase Neighboring gene pseudo Neighboring gene cutoff Neighboring gene ncRNA Neighboring gene Endoplasmic reticulum p60 Neighboring gene eukaryotic translation elongation factor 1 alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal and sequential order of nonoverlapping gene networks unraveled in mated female Drosophila. Pasquier C, et al. Life Sci Alliance, 2022 Feb. PMID 34844981, Free PMC Article
    2. Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Kharchenko PV, et al. Nature, 2011 Mar 24. PMID 21179089, Free PMC Article
    3. The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells. Landskron L, et al. Elife, 2018 Mar 27. PMID 29580384, Free PMC Article
    4. Paternal diet affects differential gene expression, but not sperm competition, in sons. Zajitschek F, et al. Biol Lett, 2017 Feb. PMID 28202685, Free PMC Article
    5. Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion. Hudson AM, et al. Development, 2019 Jan 2. PMID 30559276, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13185-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11867876..11885585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103809.3 → NP_001097279.2  uncharacterized protein Dmel_CG13185 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097279.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYB0
      Conserved Domains (6) summary
      PHA03151
      Location:4856 → 5060
      PHA03151; hypothetical protein; Provisional
      COG5271
      Location:298 → 5521
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd01460
      Location:5261 → 5526
      vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
      pfam03247
      Location:4843 → 4920
      Prothymosin; Prothymosin/parathymosin family
      cl00788
      Location:5046 → 5166
      MttA_Hcf106; mttA/Hcf106 family
      cl21455
      Location:1454 → 1603
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYB0 A8DYB0
    Q95TG7 Q95TG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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