Dlg5 Discs large 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dlg5provided by FlyBase
Official Full Name: Discs large 5provided by FlyBase
Primary source: FLYBASE:FBgn0032363
Locus tag: Dmel_CG6509
See related: AllianceGenome:FB:FBgn0032363
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6509; Dlg; dlg5; DLG5; Dmel\CG6509; LD32687
Summary: Involved in border follicle cell migration and negative regulation of hippo signaling. Located in apical part of cell. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 32F2-32F2; 2-44 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (11508399..11517081, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (11508399..11517081, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic screen for follicle epithelial morphogenesis has identified the Drosophila Dlg5 as an essential player for maintenance of apical polarity by promoting crumbs apical membrane localization.
Title: Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: discs large 5

Names: CG6509-PA; CG6509-PB; CG6509-PC; CG6509-PD; Dlg5-PA; Dlg5-PB; Dlg5-PC; Dlg5-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

11508399..11517081 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164967.2 → NP_723672.1 discs large 5, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723672.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VKG8

Related

FBpp0079832

Conserved Domains (7) summary

cd11860
Location:1594 → 1657

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

cd00992
Location:1497 → 1576

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1737 → 1904

Guanylate_kin; Guanylate kinase

pfam06476
Location:326 → 408

DUF1090; Protein of unknown function (DUF1090)

pfam10473
Location:229 → 360

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam13476
Location:165 → 333

AAA_23; AAA domain

cl17190
Location:1773 → 1905

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001273455.1 → NP_001260384.1 discs large 5, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260384.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCQ6

Conserved Domains (4) summary

cd00992
Location:1290 → 1369

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam06476
Location:326 → 408

DUF1090; Protein of unknown function (DUF1090)

pfam10473
Location:229 → 360

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam13476
Location:165 → 333

AAA_23; AAA domain
NM_001273456.1 → NP_001260385.1 discs large 5, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260385.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD90

Conserved Domains (7) summary

cd11860
Location:1593 → 1656

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

cd00992
Location:1496 → 1575

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1736 → 1903

Guanylate_kin; Guanylate kinase

pfam06476
Location:325 → 407

DUF1090; Protein of unknown function (DUF1090)

pfam10473
Location:228 → 359

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam13476
Location:164 → 332

AAA_23; AAA domain

cl17190
Location:1772 → 1904

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_135661.3 → NP_609505.1 discs large 5, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609505.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VKG8

Related

FBpp0079831

Conserved Domains (7) summary

cd11860
Location:1594 → 1657

SH3_DLG5; Src homology 3 domain of Disks Large homolog 5

cd00992
Location:1497 → 1576

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:1737 → 1904

Guanylate_kin; Guanylate kinase

pfam06476
Location:326 → 408

DUF1090; Protein of unknown function (DUF1090)

pfam10473
Location:229 → 360

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam13476
Location:165 → 333

AAA_23; AAA domain

cl17190
Location:1773 → 1905

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...