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    LManIII Lysosomal alpha-mannosidase III [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LManIIIprovided by FlyBase
    Official Full Name
    Lysosomal alpha-mannosidase IIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032066
    Locus tag
    Dmel_CG9463
    See related
    AllianceGenome:FB:FBgn0032066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9463; Dmel\CG9463
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LManIII in Genome Data Viewer
    Location:
    29F1-29F1; 2-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8765273..8768710, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8765273..8768710, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysosomal alpha-mannosidase IV Neighboring gene Lysosomal alpha-mannosidase V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
    2. Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. Yang H, et al. BMC Genomics, 2017 May 18. PMID 28521739, Free PMC Article
    3. Larvae of Drosophila melanogaster exhibit transcriptional activation of immune response pathways and antimicrobial peptides during recovery from supercooling stress. Štětina T, et al. Insect Biochem Mol Biol, 2019 Feb. PMID 30660665
    4. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
    5. Asymmetric sequence divergence of duplicate genes. Conant GC, et al. Genome Res, 2003 Sep. PMID 12952876, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase III
    Names
    CG9463-PA
    CG9463-PB
    LManIII-PA
    LManIII-PB
    NP_001285762.1
    NP_609250.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8765273..8768710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298833.1 → NP_001285762.1  lysosomal alpha-mannosidase III, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYY1, Q9VLI2
      Conserved Domains (3) summary
      cd10810
      Location:37 → 311
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:603 → 998
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:358 → 433
      Alpha-mann_mid; Alpha mannosidase, middle domain

    2. NM_135406.4 → NP_609250.2  lysosomal alpha-mannosidase III, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609250.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYY1, Q9VLI2
      Related
      FBpp0079346
      Conserved Domains (3) summary
      cd10810
      Location:37 → 311
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      pfam07748
      Location:603 → 998
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
      pfam09261
      Location:358 → 433
      Alpha-mann_mid; Alpha mannosidase, middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYY1 Q8SYY1
    Q9VLI2 Q9VLI2

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