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    RFeSP Rieske iron-sulfur protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44390, updated on 17-Dec-2024

    Summary

    Official Symbol
    RFeSPprovided by FlyBase
    Official Full Name
    Rieske iron-sulfur proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021906
    Locus tag
    Dmel_CG7361
    See related
    AllianceGenome:FB:FBgn0021906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey219; CG7361; Dmel\CG7361; dUQCRFS1; H; l(2)k11704; Noble; Q9VQ29; RfeSP; Rieske; RISP; UCRI; UQCR-RFeSP
    Summary
    Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RFeSP in Genome Data Viewer
    Location:
    22A3-22A3; 2-3 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1612429..1614160, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1612429..1614160, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hattifattener Neighboring gene no individualized sperm Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene long non-coding RNA:CR44603 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45695

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding  
    enables oxidoreductase activity  
    enables ubiquinol-cytochrome-c reductase activity  
    enables ubiquinol-cytochrome-c reductase activity  
    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    part_of respiratory chain complex III  
    part_of respiratory chain complex III  

    General protein information

    Preferred Names
    rieske iron-sulfur protein
    Names
    CG7361-PB
    CG7361-PD
    CG7361-PE
    Not out of the blue
    RFeSP-PB
    RFeSP-PD
    RFeSP-PE
    RIESKE IRON-SULFUR PROTEIN
    Ubiquinol-cytochrome C reductase iron-sulfur subunit
    Ubiquinol-cytochrome c oxidoreductase Iron-sulfur
    Ubiquinol-cytochrome c reductase rieske iron sulfur protein
    complex III
    rieske iron sulfur protein
    rieske iron sulphur protein
    rieske iron- sulfur protein of complex III
    NP_001259876.1
    NP_524748.2
    NP_722715.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1612429..1614160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272947.1 → NP_001259876.1  rieske iron-sulfur protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    2. NM_080009.4 → NP_524748.2  rieske iron-sulfur protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524748.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    3. NM_164426.3 → NP_722715.1  rieske iron-sulfur protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Related
      FBpp0077581
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
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