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    CAH3 Carbonic anhydrase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAH3provided by FlyBase
    Official Full Name
    Carbonic anhydrase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0030056
    Locus tag
    Dmel_CG11284
    See related
    AllianceGenome:FB:FBgn0030056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11284; CG11285; Dmel\CG11284
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH3 in Genome Data Viewer
    Location:
    8A1-8A2; 1-24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8681252..8688760)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8575285..8582793)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ocelliless Neighboring gene rubicon Neighboring gene Palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized protein Neighboring gene 8-oxoguanine DNA glycosylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae. Aby E, et al. Fly (Austin), 2013 Oct-Dec. PMID 24091420, Free PMC Article
    2. Characterization of Drosophila palmitoyl-protein thioesterase 1. Glaser RL, et al. Gene, 2003 Jul 17. PMID 12909364
    3. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    4. Cloning of the neurodegeneration gene drop-dead and characterization of additional phenotypes of its mutation. Blumenthal EM. Fly (Austin), 2008 Jul-Aug. PMID 18719404, Free PMC Article
    5. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 3
    Names
    CAH3-PA
    CAH3-PB
    CAH3-PC
    CAH3-PD
    CAH3-PE
    CG11284-PA
    CG11284-PB
    CG11284-PC
    CG11284-PD
    CG11284-PE
    NP_001259349.1
    NP_001259350.1
    NP_001259351.1
    NP_001285023.1
    NP_572497.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8681252..8688760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298094.1 → NP_001285023.1  carbonic anhydrase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3C8
      Conserved Domains (1) summary
      cd00326
      Location:4 → 233
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_132269.3 → NP_572497.1  carbonic anhydrase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3C8
      Related
      FBpp0071167
      Conserved Domains (1) summary
      cd00326
      Location:4 → 233
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. NM_001272422.1 → NP_001259351.1  carbonic anhydrase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3C8
      Conserved Domains (1) summary
      cd00326
      Location:4 → 233
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    4. NM_001272421.1 → NP_001259350.1  carbonic anhydrase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3C8
      Conserved Domains (1) summary
      cd00326
      Location:4 → 233
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    5. NM_001272420.1 → NP_001259349.1  carbonic anhydrase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3C8
      Conserved Domains (1) summary
      cd00326
      Location:4 → 233
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3C8 Q9W3C8

    Gene LinkOut

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