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    Josd Josephin domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Josdprovided by FlyBase
    Official Full Name
    Josephin domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029853
    Locus tag
    Dmel_CG3781
    See related
    AllianceGenome:FB:FBgn0029853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3781; Dmel\CG3781; JosD2; Q9W422
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to several human genes including JOSD1 (Josephin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Josd in Genome Data Viewer
    Location:
    5E3-5E3; 1-16 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6261169..6262119)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6155202..6156152)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rabconnectin-3A Neighboring gene schlank Neighboring gene Spliceosomal protein on the X Neighboring gene Spt6 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-5E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies using Drosophila melanogaster mutants. Sousa E Silva R, et al. Front Mol Neurosci, 2023. PMID 37008788, Free PMC Article
    2. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27444016, Free PMC Article
    3. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Yang CS, et al. Cell Death Differ, 2014 Apr. PMID 24362437, Free PMC Article
    4. Genome-scale analysis of positionally relocated genes. Bhutkar A, et al. Genome Res, 2007 Dec. PMID 17989252, Free PMC Article
    5. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    josephin domain containing
    Names
    CG3781-PA
    Josd-PA
    NP_572303.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6261169..6262119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132075.4 → NP_572303.4  josephin domain containing [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572303.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MTV0, Q9W422
      UniProtKB/TrEMBL
      C4XVM0
      Related
      FBpp0070860
      Conserved Domains (1) summary
      pfam02099
      Location:44 → 184
      Josephin; Josephin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W422.3 Q9W422

    Gene LinkOut

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