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    Prp19 Pre-RNA processing factor 19 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prp19provided by FlyBase
    Official Full Name
    Pre-RNA processing factor 19provided by FlyBase
    Primary source
    FLYBASE:FBgn0261119
    Locus tag
    Dmel_CG5519
    See related
    AllianceGenome:FB:FBgn0261119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD02793; CG5519; Dmel\CG5519; dPrp19; dPRP19; EC2-11; Gbp; GPB; l(2)07838; prp19; PRP19
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Involved in chromatin organization and regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head. Used to study syndromic intellectual disability. Orthologous to human PRPF19 (pre-mRNA processing factor 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prp19 in Genome Data Viewer
    Location:
    55C9-55C9; 2-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18447361..18451041, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14334866..14338546, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene TRPL translocation defect 14 Neighboring gene scruin like at the midline Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene roswell Neighboring gene Dynein axonemal assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. Garschall K, et al. NPJ Aging Mech Dis, 2017. PMID 28649423, Free PMC Article
    2. Up-regulated expression of Ran reveals its potential role to deltamethrin stress in Kc cells. Liu W, et al. Gene, 2016 May 25. PMID 26924245
    3. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Chen ZS, et al. Cell Death Dis, 2021 Feb 2. PMID 33542212, Free PMC Article
    4. Spliceosome malfunction causes neurodevelopmental disorders with overlapping features. Li D, et al. J Clin Invest, 2024 Jan 2. PMID 37962958, Free PMC Article
    5. Ancient origin of animal U-box ubiquitin ligases. Marín I. BMC Evol Biol, 2010 Oct 27. PMID 20979629, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
      Title: A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
    2. Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes.
      Title: Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes.
    3. the Drosophila faint sausage (fas) locus, which is implicated in epithelial morphogenesis and has previously been reported to encode a secreted immunoglobulin domain protein, in fact encodes a subunit of the spliceosome-activating Prp19 complex, which is essential for efficient pre-mRNA splicing
      Title: Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Prp19 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pre-RNA processing factor 19
    Names
    CG5519-PA
    GTP-binding regulatory protein beta chain
    NM 079059.2
    Prp19-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18447361..18451041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079059.3 → NP_523783.1  Pre-RNA processing factor 19 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KLW9
      Related
      FBpp0085902
      Conserved Domains (5) summary
      smart00504
      Location:2 → 68
      Ubox; Modified RING finger domain
      COG2319
      Location:225 → 505
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:210 → 503
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08606
      Location:69 → 132
      Prp19; Prp19/Pso4-like
      sd00039
      Location:269 → 305
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24055 Q24055
    Q7KLW9 Q7KLW9

    Gene LinkOut

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