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    Gyc32E Guanylyl cyclase at 32E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gyc32Eprovided by FlyBase
    Official Full Name
    Guanylyl cyclase at 32Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010197
    Locus tag
    Dmel_CG33114
    See related
    AllianceGenome:FB:FBgn0010197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33114; CG6275; Cyg1; Dmel\CG33114; DMRGC; GC; GYC 32E; Gyc-r
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in adult head; egg chamber; germarium; nurse cell; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gyc32E in Genome Data Viewer
    Location:
    32D5-32D5; 2-44 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11138759..11149101, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11138759..11149101, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homogentisate 1,2-dioxygenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ca2+-channel-protein-beta-subunit Neighboring gene Vitelline membrane 32E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system. Liu W, et al. J Biol Chem, 1995 May 26. PMID 7759483
    2. A membrane guanylate cyclase Drosophila homolog gene exhibits maternal and zygotic expression. Gigliotti S, et al. Dev Biol, 1993 Oct. PMID 8104831
    3. STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains. Bicker G. Bioessays, 2005 May. PMID 15832386
    4. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
    5. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob JC, et al. J Neurosci, 2004 Jul 28. PMID 15282266, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Larvae with mutations in the gene dgcalpha1, which encodes a soluble guanylyl cyclase subunit, have increases in foraging locomotion.
      Title: Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanylate cyclase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cGMP-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylyl cyclase at 32E
    Names
    CG33114-PB
    CG33114-PD
    CG33114-PG
    Gyc32E-PB
    Gyc32E-PD
    Gyc32E-PG
    guanyl cyclase at 32E
    guanylate cyclase receptor-type
    NP_001097148.1
    NP_001285834.1
    NP_788027.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11138759..11149101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298905.1 → NP_001285834.1  guanylyl cyclase at 32E, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J5N3
      Conserved Domains (7) summary
      PHA02988
      Location:498 → 790
      PHA02988; hypothetical protein; Provisional
      smart00044
      Location:829 → 1021
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:514 → 796
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:856 → 1040
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:59 → 391
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:811 → 850
      HNOBA; Heme NO binding associated
      cl10011
      Location:44 → 412
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    2. NM_001103678.2 → NP_001097148.1  guanylyl cyclase at 32E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYZ3
      Conserved Domains (7) summary
      cd06370
      Location:44 → 448
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      PHA02988
      Location:534 → 826
      PHA02988; hypothetical protein; Provisional
      smart00044
      Location:865 → 1057
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:550 → 832
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:892 → 1076
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:59 → 427
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:847 → 886
      HNOBA; Heme NO binding associated

    3. NM_176013.2 → NP_788027.1  guanylyl cyclase at 32E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07553, Q9VKI9
      Related
      FBpp0310220
      Conserved Domains (7) summary
      cd06370
      Location:44 → 420
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      PHA02988
      Location:506 → 798
      PHA02988; hypothetical protein; Provisional
      smart00044
      Location:837 → 1029
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:522 → 804
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:864 → 1048
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:59 → 399
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:819 → 858
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYZ3 A8DYZ3
    Q07553.4 Q07553
    X2J5N3 X2J5N3

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