inv invected [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: invprovided by FlyBase
Official Full Name: invectedprovided by FlyBase
Primary source: FLYBASE:FBgn0001269
Locus tag: Dmel_CG17835
See related: AllianceGenome:FB:FBgn0001269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17835; Dmel\CG17835; Engrailed/Invected; er; in; Inv; INV; IV
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; imaginal disc-derived wing vein specification; and neuroblast fate determination. Predicted to be active in nucleus. Is expressed in several structures, including clypeo-labral primordium; dorsal ectoderm; dorsal ectoderm anlage; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Orthologous to human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11474465..11509695)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7361970..7397200)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in compartment pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc anterior/posterior pattern formation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

Names: CG17835-PB; CG17835-PD; CG17835-PE; engrailed-invected; engrailed-related; inv-PB; inv-PD; inv-PE; transcript group IV

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The following sections contain reference sequences that belong to a specific genome build. Explain