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    Dolk Dolichol kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dolkprovided by FlyBase
    Official Full Name
    Dolichol kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034141
    Locus tag
    Dmel_CG8311
    See related
    AllianceGenome:FB:FBgn0034141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8311; Dmel\CG8311
    Summary
    Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dolk in Genome Data Viewer
    Location:
    53C9-53C9; 2-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16587045..16589184, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12474550..12476689, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44375 Neighboring gene Cyclin-dependent kinase 4 Neighboring gene Ribosomal protein LP2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. Lorén CE, et al. Genes Cells, 2001 Jun. PMID 11442633, Free PMC Article
    2. Wun2-mediated integrin recycling promotes apoptotic cell clearance in Drosophila melanogaster. Gao N, et al. Cell Death Differ, 2022 Dec. PMID 35840760, Free PMC Article
    3. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    4. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article
    5. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dolichol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichyl monophosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dolichol kinase
    Names
    CG8311-PA
    Dolk-PA
    NP_611139.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16587045..16589184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137295.3 → NP_611139.1  dolichol kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAI1, B5RIH4
      Related
      FBpp0086267
      Conserved Domains (1) summary
      cl21502
      Location:305 → 495
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAI1 A1ZAI1
    Q8SX00 Q8SX00

    Gene LinkOut

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