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    Rcc1 Regulator of chromosome condensation 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rcc1provided by FlyBase
    Official Full Name
    Regulator of chromosome condensation 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0002638
    Locus tag
    Dmel_CG10480
    See related
    AllianceGenome:FB:FBgn0002638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bj1; Bj1; BJ1; CG10480; CG18640 (Bj1); Dmel\CG10480; dRCC1; inxs; RanGEF; RCC1; sdt
    Summary
    Enables chromatin binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; regulation of neurogenesis; and regulation of nucleocytoplasmic transport. Located in condensed chromosome and nucleus. Is expressed in several structures, including CNS glial cell; female germline cell; ganglia; head epidermis primordium; and neuroblasts. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rcc1 in Genome Data Viewer
    Location:
    65A1-65A1; 3-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5930262..5932773, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5923362..5925873, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EGFR adaptor protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1. Frasch M. EMBO J, 1991 May. PMID 2022188, Free PMC Article
    2. Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae. Ohtsubo M, et al. EMBO J, 1991 May. PMID 2022190, Free PMC Article
    3. RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. Dasso M. Trends Biochem Sci, 1993 Mar. PMID 8480369
    4. The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal. Joy T, et al. Dev Neurobiol, 2015 May. PMID 25312250, Free PMC Article
    5. Altered nuclear transport and the most selfish of genes. Hawley RS. Dev Cell, 2001 Sep. PMID 11702939

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Bj1 RanGEF promotes Prospero nuclear export and neuroblast self-renewal
      Title: The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal.
    2. crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 A resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome
      Title: Structure of RCC1 chromatin factor bound to the nucleosome core particle.
    3. Data show that dRCC1 is required for nuclear import of nuclear localization signal sequence (NLS)-carrying cargo molecules and for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis.
      Title: The Drosophila RCC1 homolog, Bj1, regulates nucleocytoplasmic transport and neural differentiation during Drosophila development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of chromosome condensation 1
    Names
    Bj1 protein
    CG10480-PA
    CG10480-PB
    CG10480-PC
    Rcc1-PA
    Rcc1-PB
    Rcc1-PC
    in excess
    regulator of chromosome condensation 1 ortholog
    side-out

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5930262..5932773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079219.3 → NP_523943.1  regulator of chromosome condensation 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1J1, P25171, Q9VRR5
      Related
      FBpp0076782
      Conserved Domains (2) summary
      pfam00415
      Location:363 → 414
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 → 158
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. NM_168152.3 → NP_729119.1  regulator of chromosome condensation 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1J1, P25171, Q9VRR5
      Related
      FBpp0076784
      Conserved Domains (2) summary
      pfam00415
      Location:363 → 414
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 → 158
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    3. NM_168151.3 → NP_729118.1  regulator of chromosome condensation 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1J1, P25171, Q9VRR5
      Related
      FBpp0076783
      Conserved Domains (2) summary
      pfam00415
      Location:363 → 414
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 → 158
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25171.2 P25171

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