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    fax failed axon connections [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39826, updated on 17-Dec-2024

    Summary

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    Official Symbol
    faxprovided by FlyBase
    Official Full Name
    failed axon connectionsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014163
    Locus tag
    Dmel_CG4609
    See related
    AllianceGenome:FB:FBgn0014163
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.34; anon-WO0172774.62; anon-WO0172774.63; anon-WO0172774.65; anon-WO0172774.66; anon-WO0172774.67; anon-WO0172774.68; anon-WO0172774.69; CG4609; clone 1.34; Dmel\CG4609; fac; Fax; FAX
    Summary
    Involved in axonogenesis and female germ-line stem cell population maintenance. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult brain; adult brain cell body rind; adult gnathal ganglion; female germline cell; and synaptic neuropil domain. Orthologous to human FAXC (failed axon connections homolog, metaxin like GST domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fax in Genome Data Viewer
    Location:
    72E5-72F1; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16402796..16411828, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16395896..16404928, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RING-associated factor 2 Neighboring gene uncharacterized protein Neighboring gene Gag-related Neighboring gene Serine incorporator Neighboring gene Glutamyl-tRNA synthetase, mitochondrial Neighboring gene Tyrosyl-tRNA synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Liebl EC, et al. Neuron, 2000 Apr. PMID 10798396
    2. Analysis of Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches. Fabre B, et al. Proteomics, 2016 Aug. PMID 27029218, Free PMC Article
    3. Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization. Lee S, et al. Mech Dev, 2008 Sep-Oct. PMID 18655828
    4. A new BCR-ABL1 Drosophila model as a powerful tool to elucidate the pathogenesis and progression of chronic myeloid leukemia. Bernardoni R, et al. Haematologica, 2019 Apr. PMID 30409797, Free PMC Article
    5. Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium. Dong Z, et al. BMC Biol, 2023 Jun 20. PMID 37340484, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axonogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    failed axon connections
    Names
    CG4609-PA
    CG4609-PB
    CG4609-PC
    CG4609-PD
    CG4609-PE
    CG4609-PF
    failed axonal connections
    fax-PA
    fax-PB
    fax-PC
    fax-PD
    fax-PE
    fax-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16402796..16411828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079382.7 → NP_524106.3  failed axon connections, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524106.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RI5, Q9VV57
      UniProtKB/TrEMBL
      Q24036
      Related
      FBpp0075170
      Conserved Domains (2) summary
      cd03193
      Location:272 → 343
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cd03080
      Location:105 → 179
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...

    2. NM_001014586.4 → NP_001014586.1  failed axon connections, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPC0, Q59E29
      Conserved Domains (2) summary
      cd03193
      Location:133 → 204
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cl00388
      Location:4 → 43
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_176336.5 → NP_788514.1  failed axon connections, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788514.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPC0, Q86BI4
      Related
      FBpp0075171
      Conserved Domains (2) summary
      cd03193
      Location:136 → 207
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cl00388
      Location:4 → 43
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    4. NM_001275016.1 → NP_001261945.1  failed axon connections, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPC0, M9PFH6
      Conserved Domains (2) summary
      cd03193
      Location:125 → 196
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cl00388
      Location:1 → 35
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    5. NM_001275017.1 → NP_001261946.1  failed axon connections, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPC0, M9PFW1
      Conserved Domains (2) summary
      cd03193
      Location:128 → 199
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cl00388
      Location:1 → 35
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    6. NM_001014587.4 → NP_001014587.1  failed axon connections, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24036, Q59E30
      Conserved Domains (2) summary
      cd03193
      Location:269 → 340
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cd03080
      Location:105 → 179
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFH6 M9PFH6
    M9PFW1 M9PFW1
    Q24036 Q24036
    Q59E29 Q59E29
    Q59E30 Q59E30
    Q86BI4 Q86BI4
    Q95RI5.1 Q95RI5

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