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    CG3191 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3191provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023525
    Locus tag
    Dmel_CG3191
    See related
    AllianceGenome:FB:FBgn0023525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    62D9.a; BEST:GM01072; CG18842; Dmel\CG3191; EG:30B8.3
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; embryonic head sensory system; and larval labral sensory complex. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3191 in Genome Data Viewer
    Location:
    2F2-2F2; 1-0.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2250145..2251993, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2144178..2146026, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 2a Neighboring gene crooked neck Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the human crooked neck gene by comparative gene identification. Lai CH, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342225
    2. Microarray analysis of Drosophila development during metamorphosis. White KP, et al. Science, 1999 Dec 10. PMID 10591654
    3. Aβ42 Expressing Drosophila melanogaster Model for Alzheimer's Disease: Quantitative Proteomics Identifies Altered Protein Dynamics of Relevance to Neurodegeneration. Deolankar SC, et al. OMICS, 2022 Jan. PMID 35006003
    4. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article
    5. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Benos PV, et al. Genome Res, 2001 May. PMID 11337470, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3191-PA
    CG3191-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2250145..2251993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166934.2 → NP_726804.1  uncharacterized protein Dmel_CG3191, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NER9, O46073, Q95R34
      Related
      FBpp0070401
      Conserved Domains (1) summary
      cd00170
      Location:114 → 263
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_001258557.2 → NP_001245486.2  uncharacterized protein Dmel_CG3191, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245486.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NER9, O46073, Q95R34
      Conserved Domains (1) summary
      cd00170
      Location:114 → 263
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46073 O46073
    Q95R34 Q95R34

    Gene LinkOut

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