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    CG15923 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42443, updated on 4-Jan-2025

    Summary

    Official Symbol
    CG15923provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038814
    Locus tag
    Dmel_CG15923
    See related
    AllianceGenome:FB:FBgn0038814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15923
    Summary
    Predicted to be involved in cilium assembly. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Is expressed in adult brain. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See CG15923 in Genome Data Viewer
    Location:
    92F3-92F3; 3-69 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20611251..20616901, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16436973..16442623, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein Neighboring gene Hairless

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly  
    involved_in cilium assembly  
    Component Evidence Code Pubs
    part_of MKS complex  
    is_active_in ciliary transition zone  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG15923-PB
    CG15923-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20611251..20616901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104376.3 → NP_001097846.1  uncharacterized protein Dmel_CG15923, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN50, Q9VDK3
      Conserved Domains (1) summary
      pfam09773
      Location:173 → 967
      Meckelin; Meckelin (Transmembrane protein 67)
    2. NM_001275840.1 → NP_001262769.1  uncharacterized protein Dmel_CG15923, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGJ7
      Conserved Domains (1) summary
      pfam09773
      Location:173 → 967
      Meckelin; Meckelin (Transmembrane protein 67)
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