PGRP-LA Peptidoglycan recognition protein LA [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-LAprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein LAprovided by FlyBase
Primary source: FLYBASE:FBgn0035975
Locus tag: Dmel_CG32042
See related: AllianceGenome:FB:FBgn0035975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18614; CG32042; CG4361; CG4384; Dmel\CG32042; PGRP; pgrp-la; PGRP-La; PGRPLA
Summary: Predicted to enable zinc ion binding activity. Involved in defense response to Gram-negative bacterium and positive regulation of peptidoglycan recognition protein signaling pathway. Is expressed in several structures, including adult head; embryonic/larval salivary gland; epithelial tube; fat body; and gut section. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67B1-67B1; 3-29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9334332..9338336)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9327432..9331436)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
Title: Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.
PGRP-LA positively regulates the Imd pathway in barrier epithelia.
Title: Functional analysis of PGRP-LA in Drosophila immunity.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables N-acetylmuramoyl-L-alanine amidase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables peptidoglycan binding	IKR Inferred from Key Residues more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in peptidoglycan catabolic process	IKR Inferred from Key Residues more info	PubMed
involved_in positive regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peptidoglycan recognition protein LA

Names: CG32042-PC; CG32042-PD; CG32042-PE; CG32042-PF; CG32042-PG; PGRP-LA-PC; PGRP-LA-PD; PGRP-LA-PE; PGRP-LA-PF; PGRP-LA-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9334332..9338336

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206304.2 → NP_996026.1 peptidoglycan recognition protein LA, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996026.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T64, Q9BLX5, Q9GNK6, Q9GNK7, Q9VSV7, Q9VSV8

Conserved Domains (1) summary

smart00701
Location:181 → 322

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_206305.2 → NP_996027.1 peptidoglycan recognition protein LA, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996027.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T64
NM_001274694.1 → NP_001261623.1 peptidoglycan recognition protein LA, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261623.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEM5

Conserved Domains (2) summary

cl02447
Location:79 → 124

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02712
Location:1 → 92

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
NM_206307.2 → NP_996029.1 peptidoglycan recognition protein LA, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996029.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T64

Conserved Domains (1) summary

smart00701
Location:112 → 253

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_206306.2 → NP_996028.1 peptidoglycan recognition protein LA, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996028.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEM5

Conserved Domains (2) summary

cl02447
Location:79 → 124

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02712
Location:1 → 92

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...