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    Zip42C.1 Zinc/iron regulated transporter-related protein 42C.1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35579, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Zip42C.1provided by FlyBase
    Official Full Name
    Zinc/iron regulated transporter-related protein 42C.1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033096
    Locus tag
    Dmel_CG9428
    See related
    AllianceGenome:FB:FBgn0033096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg9428; CG9428; Dmel\CG9428; dzip1; dZip1; dZIP1; dZip42C.1; dZIP42C.1; Zip1; ZIP1; ZIP42C.1
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; detoxification of zinc ion; and zinc ion import across plasma membrane. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC39A1 (solute carrier family 39 member 1); SLC39A2 (solute carrier family 39 member 2); and SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zip42C.1 in Genome Data Viewer
    Location:
    42C6-42C6; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6716342..6717707, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2603847..2605212, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chaski Neighboring gene long non-coding RNA:CR43611 Neighboring gene mir-4975 stem loop Neighboring gene Zinc/iron regulated transporter-related protein 42C.2 Neighboring gene hulk

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease. Lang M, et al. PLoS Genet, 2012. PMID 22570624, Free PMC Article
    2. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Huang Y, et al. Cell Rep, 2014 Aug 7. PMID 25066125, Free PMC Article
    3. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Richards CD, et al. Biometals, 2015 Dec. PMID 26411574
    4. Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins. Mathews WR, et al. J Biol Chem, 2005 Jan 7. PMID 15509557
    5. Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding. Lapart JA, et al. Biochem Soc Trans, 2020 Jun 30. PMID 32491167

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila.
      Title: Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila.
    2. dZip1 and dZip2 are specific zinc transporters involved in dietary zinc absorption
      Title: Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation.
    3. Genetic manipulation of dZip1 to modulate its expression was accompanied by altered Amyloid beta peptides accumulation, resulting in changes in the neurodegeneration development, cognitive performance, and lifespan of the Alzheimer's disease flies
      Title: Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc/iron regulated transporter-related protein 42C.1
    Names
    CG9428-PA
    Zinc/iron regulated transporter-related protein 1
    Zinc/iron transporter-related protein 1
    Zip42C.1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6716342..6717707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080368.4 → NP_525107.1  Zinc/iron regulated transporter-related protein 42C.1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZR2, Q7K9B7
      Related
      FBpp0085472
      Conserved Domains (1) summary
      pfam02535
      Location:21 → 336
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZR2 Q7JZR2
    Q7K9B7 Q7K9B7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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