dx deltex [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dxprovided by FlyBase
Official Full Name: deltexprovided by FlyBase
Primary source: FLYBASE:FBgn0000524
Locus tag: Dmel_CG3929
See related: AllianceGenome:FB:FBgn0000524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3929; Deltex; Dlx; DMDELTEX; Dmel\CG3929; Dx
Summary: Enables Notch binding activity and ubiquitin protein ligase activity. Involved in several processes, including Notch receptor processing; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytosol and nucleus. Is expressed in organism. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1); DTX2 (deltex E3 ubiquitin ligase 2); and DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6B1-6B2; 1-17 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6533999..6538575)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6428032..6432608)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/beta-catenin degradation.
Title: E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation.
Alternative mechanisms of Notch activation by partitioning into distinct endosomal domains.
Title: Alternative mechanisms of Notch activation by partitioning into distinct endosomal domains.
Deltex cooperates with TRAF6 to promote apoptosis and cell migration through Eiger-independent JNK activation in Drosophila.
Title: Deltex cooperates with TRAF6 to promote apoptosis and cell migration through Eiger-independent JNK activation in Drosophila.
Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
Title: Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.
REVIEW: Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in the Regulation of Notch Signaling
Title: Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex.
Dx is involved in the cytoplasmic relocalization of Eiger from the cell membrane, thereby influencing Eiger-mediated JNK-activation process.
Title: Deltex interacts with Eiger and consequently influences the cell death in Drosophila melanogaster.
coexpression of Dx and Hrp48 activates JNK pathway to induce cell death in eye disc of Drosophila melanogaster.
Title: Synergistic interaction of Deltex and Hrp48 leads to JNK activation.
we observed that Dx together with Hrp48 can regulate Notch signaling in an Sxl-independent manner. In addition, Dx and Hrp48 displayed a synergistic effect on caspase-mediated cell death. Our results suggest that Dx and Hrp48 together negatively regulate Notch signaling in Drosophila melanogaster.
Title: Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster.
Study identified a network of competing endocytic routes mediated by Su(dx) and Dx that positively and negatively regulate N activation; have distinct requirements for ligands, membrane sterol, and endosomal trafficking components; and have different temperature sensitivities.
Title: Compensatory flux changes within an endocytic trafficking network maintain thermal robustness of Notch signaling.
It was shown that Shrub plays a pivotal rate-limiting step in late endosomal ligand-independent Notch activation, depending on the Deltex-dependent ubiquitinylation state of the receptor.
Title: Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: deltex

Names: CG3929-PA; dx-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6533999..6538575

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078509.3 → NP_511064.2 deltex [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511064.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A9YJA9, A9YJB1, A9YJB7, B3LF71, Q23985, Q86P53, Q9W3Z1

Related

FBpp0070876

Conserved Domains (3) summary

smart00678
Location:133 → 209

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd09633
Location:609 → 735

Deltex_C; Domain found at the C-terminus of deltex-like

cd00162
Location:548 → 600

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...