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    Pms2 Pms2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36705, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pms2provided by FlyBase
    Official Full Name
    Pms2provided by FlyBase
    Primary source
    FLYBASE:FBgn0011660
    Locus tag
    Dmel_CG8169
    See related
    AllianceGenome:FB:FBgn0011660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8169; Dmel\CG8169; dmlh-2; dmlh2; dpms2; Mlh2; pms2; PMS2
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to several human genes including PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pms2 in Genome Data Viewer
    Location:
    51F11-51F11; 2-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15368074..15371520, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11255579..11259025, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44371 Neighboring gene Hormone receptor 51 Neighboring gene unc-5 Neighboring gene long non-coding RNA:CR44458 Neighboring gene long non-coding RNA:CR44459 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA mismatch repair and mutation avoidance pathways. Marti TM, et al. J Cell Physiol, 2002 Apr. PMID 11920679
    2. Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila. Güneş M, et al. Sci Total Environ, 2023 Dec 15. PMID 37633389
    3. Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. Muha V, et al. PLoS Genet, 2012. PMID 22685418, Free PMC Article
    4. DNA repair in Drosophila: insights from the Drosophila genome sequence. Sekelsky JJ, et al. J Cell Biol, 2000 Jul 24. PMID 10908583, Free PMC Article
    5. Genotoxic hazard assessment of cerium oxide and magnesium oxide nanoparticles in Drosophila. Yalçın B, et al. Nanotoxicology, 2022 Apr. PMID 35818303

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pms2
    Names
    CG8169-PA
    Pms2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15368074..15371520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057675.4 → NP_477023.1  Pms2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA03, Q8T9C0
      Related
      FBpp0086520
      Conserved Domains (4) summary
      smart00853
      Location:703 → 847
      MutL_C; MutL C terminal dimerisation domain
      COG0323
      Location:26 → 880
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
      cd03484
      Location:238 → 381
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      cl00075
      Location:46 → 151
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA03 A1ZA03
    O76417 O76417
    Q8T9C0 Q8T9C0

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