U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CNT2 Concentrative nucleoside transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35914, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CNT2provided by FlyBase
    Official Full Name
    Concentrative nucleoside transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0025709
    Locus tag
    Dmel_CG8083
    See related
    AllianceGenome:FB:FBgn0025709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK00459; CG8083; CK00459; DmCnt2; Dmel\CG8083
    Summary
    Enables cyclic-di-GMP transmembrane transporter activity. Involved in positive regulation of cGAS/STING signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; gut section; and yolk nucleus. Orthologous to several human genes including SLC28A1 (solute carrier family 28 member 1) and SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CNT2 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9078721..9082374)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4966226..4969879)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene NAD kinase 2, mitochondrial

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699
    2. Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes. Segrist E, et al. Cell Rep, 2021 Dec 28. PMID 34965418, Free PMC Article
    3. Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila. Lin YH, et al. Front Cell Dev Biol, 2021. PMID 33777958, Free PMC Article
    4. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
    5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclic-di-GMP transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine ribonucleotide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cGAS/STING signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    concentrative nucleoside transporter 2
    Names
    CG8083-PA
    CG8083-PB
    CG8083-PC
    CNT2-PA
    CNT2-PB
    CNT2-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9078721..9082374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136602.5 → NP_610446.1  concentrative nucleoside transporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDP6, Q7K4A1
      Related
      FBpp0087643
      Conserved Domains (4) summary
      TIGR00804
      Location:180 → 578
      nupC; nucleoside transporter
      pfam01773
      Location:187 → 254
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:368 → 578
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:268 → 363
      Gate; Nucleoside recognition

    2. NM_206059.3 → NP_995781.1  concentrative nucleoside transporter 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDP6, Q7K4A1
      Conserved Domains (4) summary
      TIGR00804
      Location:180 → 578
      nupC; nucleoside transporter
      pfam01773
      Location:187 → 254
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:368 → 578
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:268 → 363
      Gate; Nucleoside recognition

    3. NM_206060.3 → NP_995782.1  concentrative nucleoside transporter 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7N2, F3YDP6
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 577
      nupC; nucleoside transporter
      pfam01773
      Location:186 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 577
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:267 → 362
      Gate; Nucleoside recognition
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7N2 A1Z7N2
    Q7K4A1 Q7K4A1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous