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    Klk12 kallikrein related-peptidase 12 [ Mus musculus (house mouse) ]

    Gene ID: 69511, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klk12provided by MGI
    Official Full Name
    kallikrein related-peptidase 12provided by MGI
    Primary source
    MGI:MGI:1916761
    See related
    Ensembl:ENSMUSG00000044430 AllianceGenome:MGI:1916761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KLK-L5; 2310008B01Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK12 (kallikrein related peptidase 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Klk12 in Genome Data Viewer
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43418346..43423005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43768891..43773581)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 13 Neighboring gene RIKEN cDNA 2310002F09 gene Neighboring gene kallikrein related-peptidase 11 Neighboring gene kallikrein related-peptidase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains. Murakami K, et al. Protein Pept Lett, 2014. PMID 25666037
    2. Human tissue kallikreins: physiologic roles and applications in cancer. Borgoño CA, et al. Mol Cancer Res, 2004 May. PMID 15192120
    3. Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms. Angata T, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15331780, Free PMC Article
    4. Organization and evolution of the glandular kallikrein locus in Mus musculus. Olsson AY, et al. Biochem Biophys Res Commun, 2002 Nov 29. PMID 12437987
    5. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, et al. Genomics, 2004 Jul. PMID 15203212

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein-12
    Names
    kallikrein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415883.1 → NP_001402812.1  kallikrein-12 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151989
      UniProtKB/TrEMBL
      B2RVZ0
      Related
      ENSMUSP00000103604.2, ENSMUST00000107970.8

    2. NM_027097.2 → NP_081373.1  kallikrein-12 precursor

      See identical proteins and their annotated locations for NP_081373.1

      Status: VALIDATED

      Source sequence(s)
      AC151989
      Consensus CDS
      CCDS52226.1
      UniProtKB/TrEMBL
      A0A0B6VPC8, B2RVZ0
      Related
      ENSMUSP00000014063.5, ENSMUST00000014063.6
      Conserved Domains (1) summary
      smart00020
      Location:21 → 240
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43418346..43423005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312288.2 → XP_017167777.1  kallikrein-12 isoform X1

      UniProtKB/TrEMBL
      A0A0B6VPC8, B2RVZ0
      Conserved Domains (1) summary
      smart00020
      Location:21 → 240
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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