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    Sh3tc1 SH3 domain and tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 231147, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh3tc1provided by MGI
    Official Full Name
    SH3 domain and tetratricopeptide repeats 1provided by MGI
    Primary source
    MGI:MGI:2678949
    See related
    Ensembl:ENSMUSG00000036553 AllianceGenome:MGI:2678949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631428G15
    Summary
    Is expressed in embryo mesenchyme and meninges. Orthologous to human SH3TC1 (SH3 domain and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 14.6), kidney adult (RPKM 12.2) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3tc1 in Genome Data Viewer
    Location:
    5 B3; 5 18.6 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35854524..35897331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35697180..35739987, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene HtrA serine peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene predicted gene, 31888 Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8050 Neighboring gene actin filament associated protein 1 Neighboring gene H2A histone family, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain and tetratricopeptide repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359895.1 → NP_001346824.1  SH3 domain and tetratricopeptide repeat-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122871, AK167283
      Consensus CDS
      CCDS19234.2
      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000144175.2, ENSMUST00000201511.2
      Conserved Domains (3) summary
      cd11885
      Location:313 → 367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:1163 → 1190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1166 → 1231
      TPR_12; Tetratricopeptide repeat

    2. NM_194344.2 → NP_919325.2  SH3 domain and tetratricopeptide repeat-containing protein 1

      See identical proteins and their annotated locations for NP_919325.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK150064, AK159089, BY201660, BY513538
      Consensus CDS
      CCDS19234.2
      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000070610.8, ENSMUST00000070203.14
      Conserved Domains (3) summary
      cd11885
      Location:313 → 367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:1163 → 1190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1166 → 1231
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35854524..35897331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503904.4 → XP_006503967.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006503967.1

      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000115376.2, ENSMUST00000127825.8
      Conserved Domains (3) summary
      cd11885
      Location:313 → 367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:1163 → 1190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1166 → 1231
      TPR_12; Tetratricopeptide repeat

    2. XM_036165020.1 → XP_036020913.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3TXV8, Q3UDI4
      Conserved Domains (3) summary
      cd11885
      Location:288 → 342
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:1138 → 1165
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1141 → 1206
      TPR_12; Tetratricopeptide repeat

    3. XM_036165021.1 → XP_036020914.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3TXV8, Q3UDI4
      Conserved Domains (3) summary
      cd11885
      Location:119 → 173
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:969 → 996
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:972 → 1037
      TPR_12; Tetratricopeptide repeat

    4. XM_006503905.3 → XP_006503968.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      Q6KAR4
      Conserved Domains (2) summary
      sd00006
      Location:813 → 840
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:816 → 881
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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