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    Tpm3 tropomyosin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117557, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tpm3provided by RGD
    Official Full Name
    tropomyosin 3provided by RGD
    Primary source
    RGD:621546
    See related
    EnsemblRapid:ENSRNOG00000017441 AllianceGenome:RGD:621546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpm5; TM30nm
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in brush border. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 928.6), Spleen (RPKM 397.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpm3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177812534..177842661)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175517198..175545014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189423534..189451340)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NS5A transactivated protein 4 Neighboring gene cilia and flagella associated protein 141 Neighboring gene microRNA 190b Neighboring gene transfer RNA proline (anticodon AGG) 20 Neighboring gene nucleoporin 210-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of tropomyosin-encoding gene in the kidney depends on functioning of vasopressin gene. Khegay II, et al. Biochem Genet, 2004 Feb. PMID 15068339
    2. Identification of novel alternatively spliced isoforms of the tropomyosin-encoding gene, TMnm, in the rat cochlea. Beisel KW, et al. Gene, 1994 Jun 10. PMID 8206382
    3. Splicing of two internal and four carboxyl-terminal alternative exons in nonmuscle tropomyosin 5 pre-mRNA is independently regulated during development. Dufour C, et al. J Biol Chem, 1998 Jul 17. PMID 9660825
    4. Functional effects of congenital myopathy-related mutations in gamma-tropomyosin gene. Robaszkiewicz K, et al. Biochim Biophys Acta, 2012 Oct. PMID 22749829
    5. Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Temm-Grove CJ, et al. Cell Motil Cytoskeleton, 1996. PMID 8674141

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
      Title: [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
    2. Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
      Title: Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
    3. All studied gamma-tropomyosin mutants reduced Ca-induced activation but had no effect on the inhibition of actomyosin cross-bridges.
      Title: Functional effects of congenital myopathy-related mutations in gamma-tropomyosin gene.
    4. variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
      Title: Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
    5. the main expression of Tpm3(3) takes place in the renal medulla, and its intensity differs in normal and Brattleboro diabetes insipidus mutant rats
      Title: Expression of tropomyosin-encoding gene in the kidney depends on functioning of vasopressin gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin alpha-3 chain
    Names
    gamma-tropomyosin
    nonmuscle tropomyosin 5
    tropomyosin 3, gamma
    tropomyosin non-muscle
    tropomyosin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301285.1 → NP_001288214.1  tropomyosin alpha-3 chain isoform Tpm3.12st

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.12, also known as variant 3) encodes the longest isoform (Tpm3.12st, also known as isoform 3). The encoded protein is a fast skeletal muscle isoform.
      Source sequence(s)
      FQ215580
      Related
      ENSRNOP00000035561.5, ENSRNOT00000029076.7
      Conserved Domains (3) summary
      pfam00261
      Location:49 → 283
      Tropomyosin; Tropomyosin
      pfam07851
      Location:181 → 275
      TMPIT; TMPIT-like protein
      pfam16526
      Location:14 → 73
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    2. NM_001301286.1 → NP_001288215.1  tropomyosin alpha-3 chain isoform Tpm3.3cy

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.3, also known as variant 4) differs in the 5' UTR and coding sequence compared to variant Tpm3.12. The resulting isoform (Tpm3.3cy, also known as isoform 4) has a shorter and distinct N-terminus compared to isoform Tpm3.12st.
      Source sequence(s)
      FQ215580, L24776
      UniProtKB/TrEMBL
      A6J6K0
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    3. NM_057208.2 → NP_476556.2  tropomyosin alpha-3 chain isoform Tpm3.4cy

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.4, also known as variant 1) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.4cy, also known as isoform 1) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.
      Source sequence(s)
      L24777
      UniProtKB/TrEMBL
      A6J6J8
      Related
      ENSRNOP00000109938.1, ENSRNOT00000166501.1
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 245
      Tropomyosin

    4. NM_173111.2 → NP_775134.2  tropomyosin alpha-3 chain isoform Tpm3.1cy

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (Tpm3.1, also known as variant 2) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.1cy, also known as isoform 2) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q63599, Q63600, Q63601, Q63610
      UniProtKB/TrEMBL
      A6J6J6
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177812534..177842661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232569.5 → XP_006232631.1  tropomyosin alpha-3 chain isoform X5

      Conserved Domains (2) summary
      pfam00261
      Location:49 → 283
      Tropomyosin
      pfam16526
      Location:14 → 73
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    2. XM_006232568.5 → XP_006232630.1  tropomyosin alpha-3 chain isoform X3

      UniProtKB/TrEMBL
      A0A8I6A144, A6J6J4
      Conserved Domains (1) summary
      pfam00261
      Location:49 → 283
      Tropomyosin

    3. XM_006232573.5 → XP_006232635.1  tropomyosin alpha-3 chain isoform X7

      UniProtKB/TrEMBL
      A0A140TAF0, A6J6J5
      Related
      ENSRNOP00000094091.1, ENSRNOT00000101614.2
      Conserved Domains (2) summary
      pfam00261
      Location:49 → 283
      Tropomyosin
      pfam16526
      Location:14 → 73
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    4. XM_006232572.5 → XP_006232634.1  tropomyosin alpha-3 chain isoform X6

      Conserved Domains (1) summary
      pfam00261
      Location:49 → 283
      Tropomyosin

    5. XM_006232576.5 → XP_006232638.1  tropomyosin alpha-3 chain isoform X8

      Conserved Domains (2) summary
      pfam00261
      Location:49 → 282
      Tropomyosin
      pfam16526
      Location:14 → 73
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    6. XM_006232577.5 → XP_006232639.1  tropomyosin alpha-3 chain isoform X9

      Conserved Domains (1) summary
      pfam00261
      Location:49 → 282
      Tropomyosin

    7. XM_063281193.1 → XP_063137263.1  tropomyosin alpha-3 chain isoform X1

    8. XM_006232570.5 → XP_006232632.1  tropomyosin alpha-3 chain isoform X4

      Conserved Domains (2) summary
      pfam00261
      Location:49 → 283
      Tropomyosin
      pfam16526
      Location:14 → 73
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    9. XM_063281194.1 → XP_063137264.1  tropomyosin alpha-3 chain isoform X2

    10. XM_063281196.1 → XP_063137266.1  tropomyosin alpha-3 chain isoform X11

    11. XM_063281197.1 → XP_063137267.1  tropomyosin alpha-3 chain isoform X15

      UniProtKB/TrEMBL
      A6J6K0
      Related
      ENSRNOP00000079275.2, ENSRNOT00000112248.2

    12. XM_063281195.1 → XP_063137265.1  tropomyosin alpha-3 chain isoform X10

    13. XM_006232584.5 → XP_006232646.1  tropomyosin alpha-3 chain isoform X16

      UniProtKB/TrEMBL
      A0A8L2QDD9
      Related
      ENSRNOP00000023605.4, ENSRNOT00000023605.9
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 245
      Tropomyosin

    14. XM_006232581.5 → XP_006232643.1  tropomyosin alpha-3 chain isoform X14

      Related
      ENSRNOP00000097306.2, ENSRNOT00000101991.2
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    15. XM_039101596.2 → XP_038957524.1  tropomyosin alpha-3 chain isoform X13

      UniProtKB/TrEMBL
      A0A8L2QDD2
      Related
      ENSRNOP00000023567.6, ENSRNOT00000023567.10

    16. XM_039101595.2 → XP_038957523.1  tropomyosin alpha-3 chain isoform X12

      UniProtKB/TrEMBL
      A0A8L2QDD2

    17. XM_063281200.1 → XP_063137270.1  tropomyosin alpha-3 chain isoform X20

    18. XM_063281198.1 → XP_063137268.1  tropomyosin alpha-3 chain isoform X17

    19. XM_063281199.1 → XP_063137269.1  tropomyosin alpha-3 chain isoform X19

    20. XM_039101597.2 → XP_038957525.1  tropomyosin alpha-3 chain isoform X18

      UniProtKB/TrEMBL
      A0A8I6G322
      Related
      ENSRNOP00000085183.2, ENSRNOT00000114156.2
      Conserved Domains (1) summary
      pfam00261
      Location:20 → 222
      Tropomyosin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63610.2 GenPept UniProtKB/Swiss-Prot:Q63610

    Gene LinkOut

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