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    Wac WW domain containing adaptor with coiled-coil [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307029, updated on 3-Dec-2024

    Summary

    Official Symbol
    Wacprovided by RGD
    Official Full Name
    WW domain containing adaptor with coiled-coilprovided by RGD
    Primary source
    RGD:1562407
    See related
    EnsemblRapid:ENSRNOG00000018698 AllianceGenome:RGD:1562407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562407
    Summary
    Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of macroautophagy. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Human ortholog(s) of this gene implicated in DeSanto-Shinawi syndrome. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 401.2), Lung (RPKM 347.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wac in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (60617702..60677771)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (55922686..55984286)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (60887606..60946630, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482777 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene DEAD-box helicase 5, pseudogene 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WW domain-containing adapter protein with coiled-coil

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270417.1NP_001257346.1  WW domain-containing adapter protein with coiled-coil

      See identical proteins and their annotated locations for NP_001257346.1

      Status: PROVISIONAL

      Source sequence(s)
      AB574169
      UniProtKB/TrEMBL
      A6KPM9, F1LW69, G3XEV5
      Related
      ENSRNOP00000082342.2, ENSRNOT00000116963.2
      Conserved Domains (2) summary
      pfam00397
      Location:133160
      WW; WW domain
      cl21494
      Location:423528
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      60617702..60677771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276468.1XP_063132538.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
    2. XM_039095733.2XP_038951661.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
      Related
      ENSRNOP00000055641.6, ENSRNOT00000058852.6
      Conserved Domains (3) summary
      PHA03247
      Location:172490
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:86153
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:88115
      WW; WW domain
    3. XM_063276466.1XP_063132536.1  WW domain-containing adapter protein with coiled-coil isoform X6

      UniProtKB/TrEMBL
      A6KPM9
    4. XM_063276472.1XP_063132542.1  WW domain-containing adapter protein with coiled-coil isoform X11

      UniProtKB/TrEMBL
      A6KPM9
    5. XM_063276467.1XP_063132537.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
    6. XM_039095730.2XP_038951658.1  WW domain-containing adapter protein with coiled-coil isoform X3

      UniProtKB/TrEMBL
      A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:217535
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:131198
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:133160
      WW; WW domain
    7. XM_039095738.2XP_038951666.1  WW domain-containing adapter protein with coiled-coil isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZWU8, A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:195425
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:131198
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:133160
      WW; WW domain
    8. XM_063276462.1XP_063132532.1  WW domain-containing adapter protein with coiled-coil isoform X1

      UniProtKB/TrEMBL
      A6KPM9
    9. XM_063276463.1XP_063132533.1  WW domain-containing adapter protein with coiled-coil isoform X2

      UniProtKB/TrEMBL
      A6KPM9
    10. XM_063276464.1XP_063132534.1  WW domain-containing adapter protein with coiled-coil isoform X4

      UniProtKB/TrEMBL
      A6KPM9
    11. XM_063276465.1XP_063132535.1  WW domain-containing adapter protein with coiled-coil isoform X5

      UniProtKB/TrEMBL
      A6KPM9
    12. XM_063276471.1XP_063132541.1  WW domain-containing adapter protein with coiled-coil isoform X9

      UniProtKB/TrEMBL
      A6KPM9
    13. XM_063276470.1XP_063132540.1  WW domain-containing adapter protein with coiled-coil isoform X8

      UniProtKB/TrEMBL
      A6KPM9
    14. XM_063276473.1XP_063132543.1  WW domain-containing adapter protein with coiled-coil isoform X12

      UniProtKB/TrEMBL
      A6KPM9
      Related
      ENSRNOP00000110310.1, ENSRNOT00000100553.2
    15. XM_039095734.2XP_038951662.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:172490
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:86153
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:88115
      WW; WW domain
    16. XM_063276469.1XP_063132539.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9

    RNA

    1. XR_010058876.1 RNA Sequence

    2. XR_010058875.1 RNA Sequence