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    Tcaf1 TRPM8 channel-associated factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcaf1provided by RGD
    Official Full Name
    TRPM8 channel-associated factor 1provided by RGD
    Primary source
    RGD:1565474
    See related
    EnsemblRapid:ENSRNOG00000017911 AllianceGenome:RGD:1565474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam115a; RGD1565474
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Predicted to be active in plasma membrane. Orthologous to human TCAF1 (TRPM8 channel associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 244.9), Brain (RPKM 171.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcaf1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72589710..72639304, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71589674..71639274, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (72119349..72171733, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TRPM8 channel associated factor 2C Neighboring gene TRPM8 channel-associated factor 2-like Neighboring gene olfactory receptor family 2 subfamily F member 5, pseudogene 1 Neighboring gene 40S ribosomal protein S23 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRPM8 channel-associated factor 1
    Names
    family with sequence similarity 115, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399348.1 → NP_001386277.1  TRPM8 channel-associated factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IF86, D3Z8A4, D3ZFL9
      Related
      ENSRNOP00000024428.6, ENSRNOT00000024428.9
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 890
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    2. NM_001399349.1 → NP_001386278.1  TRPM8 channel-associated factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IF86, D3Z8A4, D3ZFL9
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 890
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      72589710..72639304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286251.1 → XP_063142321.1  TRPM8 channel-associated factor 1 isoform X1

      UniProtKB/TrEMBL
      A6IF86, D3Z8A4, D3ZFL9
    Nucleotide Protein Strain
    Heading Accession and Version

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