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    Wasf1 WASP family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294568, updated on 3-Dec-2024

    Summary

    Official Symbol
    Wasf1provided by RGD
    Official Full Name
    WASP family member 1provided by RGD
    Primary source
    RGD:1561954
    See related
    EnsemblRapid:ENSRNOG00000047476 AllianceGenome:RGD:1561954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in dendritic transport of mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium and postsynapse. Orthologous to human WASF1 (WASP family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 87.4), Testes (RPKM 32.8) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wasf1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45908458..45956118)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44325815..44372999)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48456191..48503768, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 24 Neighboring gene uncharacterized LOC120098819 Neighboring gene uncharacterized LOC120098955 Neighboring gene cell division cycle 40 Neighboring gene G protein-coupled receptor 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene FIG4 phosphoinositide 5-phosphatase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC109303

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to brain-derived neurotrophic factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to brain-derived neurotrophic factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic transport of mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lamellipodium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-binding protein WASF1
    Names
    WAS protein family, member 1
    WASP family 1
    WASP family protein member 1
    protein WAVE-1
    wiskott-Aldrich syndrome protein family member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025114.2NP_001020285.1  actin-binding protein WASF1 isoform 1

      See identical proteins and their annotated locations for NP_001020285.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q5BJU7
      UniProtKB/TrEMBL
      A0A8L2QX68, A6KTC6
      Conserved Domains (1) summary
      pfam02205
      Location:494521
      WH2; WH2 motif
    2. NM_001434624.1NP_001421553.1  actin-binding protein WASF1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q5BJU7
      UniProtKB/TrEMBL
      A0A8L2QX68, A6KTC6
    3. NM_001434625.1NP_001421554.1  actin-binding protein WASF1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8L2QX68

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45908458..45956118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256586.5XP_006256648.1  actin-binding protein WASF1 isoform X1

      Related
      ENSRNOP00000064342.3, ENSRNOT00000073091.4
      Conserved Domains (1) summary
      pfam02205
      Location:494521
      WH2; WH2 motif
    2. XM_006256587.5XP_006256649.1  actin-binding protein WASF1 isoform X2

      Conserved Domains (1) summary
      pfam02205
      Location:493520
      WH2; WH2 motif