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    Rab18 RAB18, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307039, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab18provided by RGD
    Official Full Name
    RAB18, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1308905
    See related
    EnsemblRapid:ENSRNOG00000018972 AllianceGenome:RGD:1308905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; import into nucleus; and lipid droplet organization. Is active in synapse. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 439.1), Liver (RPKM 422.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab18 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (59639264..59670653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54944099..54976093)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (59844781..59876170)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14, pseudogene 4 Neighboring gene uncharacterized LOC134482727 Neighboring gene mohawk homeobox Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene DEAD-box helicase 5, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC109292

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012468.1NP_001012486.1  ras-related protein Rab-18

      See identical proteins and their annotated locations for NP_001012486.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089957
      UniProtKB/Swiss-Prot
      Q5EB77
      UniProtKB/TrEMBL
      A6KPM0
      Related
      ENSRNOP00000097816.2, ENSRNOT00000095005.2
      Conserved Domains (2) summary
      smart00175
      Location:9172
      RAB; Rab subfamily of small GTPases
      cd01863
      Location:9169
      Rab18; Rab GTPase family 18 (Rab18)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      59639264..59670653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)