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    Ranbp2 RAN binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294429, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ranbp2provided by RGD
    Official Full Name
    RAN binding protein 2provided by RGD
    Primary source
    RGD:1560047
    See related
    EnsemblRapid:ENSRNOG00000000796 AllianceGenome:RGD:1560047
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560047
    Summary
    Predicted to enable SUMO ligase activity and small GTPase binding activity. Predicted to contribute to GTPase activator activity. Involved in response to amphetamine. Located in cytoplasmic periphery of the nuclear pore complex. Part of nuclear pore cytoplasmic filaments. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to human RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 581.3), Thymus (RPKM 505.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ranbp2 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (26984520..27036573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26442156..26493481)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28027054..28076664) , (28365538..28375676)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene uncharacterized LOC134483907 Neighboring gene coiled-coil domain containing 138 Neighboring gene ectodysplasin-A receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in NLS-bearing protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SUMO ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic periphery of the nuclear pore complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore cytoplasmic filaments IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore cytoplasmic filaments ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 SUMO-protein ligase RanBP2
    NP_001178533.1
    XP_038954525.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191604.1NP_001178533.1  E3 SUMO-protein ligase RanBP2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      M0R3M4
      Related
      ENSRNOP00000063941.2, ENSRNOT00000071386.5
      Conserved Domains (12) summary
      TIGR02795
      Location:32138
      tol_pal_ybgF; tol-pal system protein YbgF
      cd01926
      Location:29283086
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd13177
      Location:19022018
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd13178
      Location:27892905
      RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
      cd14684
      Location:11801296
      RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
      cd14685
      Location:21992315
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00025
      Location:13501369
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:6092
      TPR_1; Tetratricopeptide repeat
      pfam00641
      Location:14731502
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam12185
      Location:25792638
      IR1-M; Nup358/RanBP2 E3 ligase domain
      cl23782
      Location:839925
      RCR; Chitin synthesis regulation, resistance to Congo red

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      26984520..27036573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098597.2XP_038954525.1  E3 SUMO-protein ligase RanBP2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC36, M0R3M4
      Related
      ENSRNOP00000077936.1, ENSRNOT00000114220.2
      Conserved Domains (10) summary
      COG0457
      Location:18126
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd01926
      Location:29543112
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
      cd13177
      Location:19022018
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd13178
      Location:28152931
      RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
      cd14684
      Location:11801296
      RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
      cd14685
      Location:21992315
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00025
      Location:13501369
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00006
      Location:5989
      TPR; TPR repeat [structural motif]
      pfam00641
      Location:14731502
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam12185
      Location:26052663
      IR1-M; Nup358/RanBP2 E3 ligase domain