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    Ash1l ASH1 like histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310638, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ash1lprovided by RGD
    Official Full Name
    ASH1 like histone lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1306350
    See related
    EnsemblRapid:ENSRNOG00000020386 AllianceGenome:RGD:1306350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone H3K36 methyltransferase activity; histone H3K4 methyltransferase activity; and histone H3K9 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including decidualization; tarsal gland development; and uterine gland development. Predicted to be located in Golgi apparatus and nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 262.8), Kidney (RPKM 262.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ash1l in Genome Data Viewer
    Location:
    2q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176644393..176780848)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174346267..174483057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188252592..188389251)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene misato mitochondrial distribution and morphology regulator 1 Neighboring gene death associated protein 3 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene RUN and SH3 domain containing 1 Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K4 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sebaceous gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tarsal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within uterine gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within uterus morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase ASH1L
    Names
    ash1 (absent, small, or homeotic)-like
    probable histone-lysine N-methyltransferase ASH1L
    NP_001101159.1
    XP_008759376.1
    XP_008759377.1
    XP_008759380.1
    XP_008759381.1
    XP_038958241.1
    XP_038958243.2
    XP_063137913.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107689.2NP_001101159.1  histone-lysine N-methyltransferase ASH1L

      See identical proteins and their annotated locations for NP_001101159.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K2W6, A6J6B3, D3ZKH4
      Related
      ENSRNOP00000072404.1, ENSRNOT00000085690.3
      Conserved Domains (5) summary
      cd05525
      Location:23922497
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20422093
      AWS; associated with SET domains
      smart00317
      Location:20962216
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd04717
      Location:26142748
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25352577
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176644393..176780848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761159.4XP_008759381.1  histone-lysine N-methyltransferase ASH1L isoform X2

      See identical proteins and their annotated locations for XP_008759381.1

      UniProtKB/TrEMBL
      D3ZKH4
      Conserved Domains (5) summary
      cd05525
      Location:24322537
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20822133
      AWS; associated with SET domains
      cd04717
      Location:26542788
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25752617
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
      cd19174
      Location:21362276
      SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
    2. XM_008761158.3XP_008759380.1  histone-lysine N-methyltransferase ASH1L isoform X2

      See identical proteins and their annotated locations for XP_008759380.1

      UniProtKB/TrEMBL
      D3ZKH4
      Conserved Domains (5) summary
      cd05525
      Location:24322537
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20822133
      AWS; associated with SET domains
      cd04717
      Location:26542788
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25752617
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
      cd19174
      Location:21362276
      SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
    3. XM_039102313.2XP_038958241.1  histone-lysine N-methyltransferase ASH1L isoform X2

      UniProtKB/TrEMBL
      D3ZKH4
      Conserved Domains (5) summary
      cd05525
      Location:24322537
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20822133
      AWS; associated with SET domains
      cd04717
      Location:26542788
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25752617
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
      cd19174
      Location:21362276
      SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
    4. XM_008761155.4XP_008759377.1  histone-lysine N-methyltransferase ASH1L isoform X2

      See identical proteins and their annotated locations for XP_008759377.1

      UniProtKB/TrEMBL
      D3ZKH4
      Related
      ENSRNOP00000027629.8, ENSRNOT00000027629.9
      Conserved Domains (5) summary
      cd05525
      Location:24322537
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20822133
      AWS; associated with SET domains
      cd04717
      Location:26542788
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25752617
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
      cd19174
      Location:21362276
      SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
    5. XM_008761154.4XP_008759376.1  histone-lysine N-methyltransferase ASH1L isoform X2

      See identical proteins and their annotated locations for XP_008759376.1

      UniProtKB/TrEMBL
      D3ZKH4
      Conserved Domains (5) summary
      cd05525
      Location:24322537
      Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...
      smart00570
      Location:20822133
      AWS; associated with SET domains
      cd04717
      Location:26542788
      BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...
      cd15548
      Location:25752617
      PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
      cd19174
      Location:21362276
      SET_ASH1L; SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins
    6. XM_039102315.2XP_038958243.2  histone-lysine N-methyltransferase ASH1L isoform X3

    7. XM_063281843.1XP_063137913.1  histone-lysine N-methyltransferase ASH1L isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1E5, D3ZKH4
      Related
      ENSRNOP00000086010.1, ENSRNOT00000115989.2

    RNA

    1. XR_005500293.2 RNA Sequence

    2. XR_010063608.1 RNA Sequence