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    Arl4d ARF like GTPase 4D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303559, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl4dprovided by RGD
    Official Full Name
    ARF like GTPase 4Dprovided by RGD
    Primary source
    RGD:1306875
    See related
    EnsemblRapid:ENSRNOG00000020770 AllianceGenome:RGD:1306875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arf4l
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in nucleus. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL4D (ARF like GTPase 4D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 112.6), Lung (RPKM 105.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl4d in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87092276..87103079)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86592054..86602843)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89577556..89580368)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene Sin3A associated protein 18, pseudogene 1 Neighboring gene DEAH-box helicase 8 Neighboring gene RNA polymerase II, I and III subunit L, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. Lin CY, et al. J Cell Sci, 2002 Dec 1. PMID 12414990
    2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Hofmann I, et al. Curr Biol, 2007 Apr 17. PMID 17398095
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 4D
    Names
    ADP-ribosylation factor like GTPase 4D
    ADP-ribosylation factor-like 4D
    neuroprotective protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107052.1 → NP_001100522.1  ADP-ribosylation factor-like protein 4D

      See identical proteins and their annotated locations for NP_001100522.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Related
      ENSRNOP00000028178.3, ENSRNOT00000028178.6
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87092276..87103079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269145.1 → XP_063125215.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Related
      ENSRNOP00000088311.1, ENSRNOT00000117067.2

    2. XM_063269151.1 → XP_063125221.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Related
      ENSRNOP00000096869.1, ENSRNOT00000110523.2

    3. XM_063269154.1 → XP_063125224.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    4. XM_063269142.1 → XP_063125212.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    5. XM_063269146.1 → XP_063125216.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Related
      ENSRNOP00000094427.1, ENSRNOT00000116240.2

    6. XM_063269147.1 → XP_063125217.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    7. XM_063269149.1 → XP_063125219.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    8. XM_039086100.2 → XP_038942028.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    9. XM_039086103.2 → XP_038942031.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    10. XM_039086104.2 → XP_038942032.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    11. XM_063269144.1 → XP_063125214.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    12. XM_063269152.1 → XP_063125222.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    13. XM_063269143.1 → XP_063125213.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    14. XM_063269156.1 → XP_063125226.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    15. XM_063269148.1 → XP_063125218.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    16. XM_063269150.1 → XP_063125220.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    17. XM_063269153.1 → XP_063125223.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    18. XM_063269155.1 → XP_063125225.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8

    19. XM_008768054.4 → XP_008766276.1  ADP-ribosylation factor-like protein 4D isoform X1

      See identical proteins and their annotated locations for XP_008766276.1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    20. XM_017597322.3 → XP_017452811.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    21. XM_039086105.2 → XP_038942033.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPR4, B2RZ70, B3STT8
      Conserved Domains (1) summary
      cd04152
      Location:19 → 201
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
    Nucleotide Protein Strain
    Heading Accession and Version

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