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    Anp32e acidic nuclear phosphoprotein 32 family member E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anp32eprovided by RGD
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Eprovided by RGD
    Primary source
    RGD:1310611
    See related
    EnsemblRapid:ENSRNOG00000021168 AllianceGenome:RGD:1310611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including histone chaperone activity; phosphatase inhibitor activity; and protein folding chaperone. Predicted to be involved in regulation of apoptotic process. Predicted to be located in cytoplasmic vesicle. Predicted to be part of Swr1 complex. Predicted to be active in several cellular components, including cytoplasmic vesicle membrane; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human ANP32E (acidic nuclear phosphoprotein 32 family member E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 313.0), Spleen (RPKM 224.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anp32e in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186161520..186177984)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183472600..183489057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198040573..198057005)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 14 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 like 1 Neighboring gene pleckstrin homology domain containing O1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of CPD1 during postnatal development in the mouse cerebellum. Radrizzani M, et al. Brain Res, 2001 Jul 13. PMID 11430900
    2. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511
    3. The Anp32 family of proteins containing leucine-rich repeats. Matilla A, et al. Cerebellum, 2005. PMID 15895553
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Swr1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member E
    Names
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013200.1 → NP_001013218.1  acidic leucine-rich nuclear phosphoprotein 32 family member E

      See identical proteins and their annotated locations for NP_001013218.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083744
      UniProtKB/Swiss-Prot
      Q5XIE0
      UniProtKB/TrEMBL
      A6K337
      Related
      ENSRNOP00000077268.1, ENSRNOT00000120288.2
      Conserved Domains (2) summary
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34 → 146
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186161520..186177984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102698.2 → XP_038958626.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

      Related
      ENSRNOP00000028744.5, ENSRNOT00000028744.8
      Conserved Domains (2) summary
      sd00033
      Location:44 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34 → 146
      LRR_9; Leucine-rich repeat

    2. XM_017590976.3 → XP_017446465.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIE0.1 GenPept UniProtKB/Swiss-Prot:Q5XIE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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