Recql5 RecQ protein-like 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Recql5provided by MGI
Official Full Name: RecQ protein-like 5provided by MGI
Primary source: MGI:MGI:2156841
See related: Ensembl:ENSMUSG00000020752 AllianceGenome:MGI:2156841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RecQ5; Recq5b; Recql5b
Summary: Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription preinitiation complex. Predicted to be active in cytoplasm; nucleus; and replication fork. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 8.0), large intestine adult (RPKM 8.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 80.91 cM; 11 E2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115783421..115824339, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115892595..115933514, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes.
Title: A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes.
Recql5 protects the liver against LPS/D-Gal-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.
Title: Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.
Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc(min) mice.
Title: Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I poisoning.
Title: Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.
Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
Title: RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to camptothecin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to camptothecin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in chromosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in replication fork	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	ISO Inferred from Sequence Orthology more info
part_of transcription preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of transcription preinitiation complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent DNA helicase Q5

Names: DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RECQL5beta

NP_569721.1

EC 5.6.2.4

XP_006532421.1

EC 5.6.2.4

XP_006532422.1

EC 5.6.2.4

XP_006532424.1

EC 5.6.2.4

XP_006532425.1

EC 5.6.2.4

XP_006532426.1

EC 5.6.2.4

XP_030101474.1

EC 5.6.2.4

XP_036012259.1

EC 5.6.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130454.2 → NP_569721.1 ATP-dependent DNA helicase Q5

See identical proteins and their annotated locations for NP_569721.1

Status: VALIDATED

Source sequence(s)

AK049269, AL645647, AW049927, BC059000

Consensus CDS

CCDS25650.1

UniProtKB/Swiss-Prot

Q8BQD7, Q8C7T6, Q8VID3, Q8VID5

Related

ENSMUSP00000021097.4, ENSMUST00000021097.10

Conserved Domains (2) summary

COG0514
Location:15 → 439

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:626 → 817

RecQ5; RecQ helicase protein-like 5 (RecQ5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115783421..115824339 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532361.5 → XP_006532424.1 ATP-dependent DNA helicase Q5 isoform X4

See identical proteins and their annotated locations for XP_006532424.1

Conserved Domains (2) summary

COG0514
Location:1 → 133

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:320 → 508

RecQ5; RecQ helicase protein-like 5 (RecQ5)
XM_006532359.5 → XP_006532422.1 ATP-dependent DNA helicase Q5 isoform X3

Conserved Domains (2) summary

COG0514
Location:6 → 398

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:585 → 773

RecQ5; RecQ helicase protein-like 5 (RecQ5)
XM_006532358.5 → XP_006532421.1 ATP-dependent DNA helicase Q5 isoform X1

Conserved Domains (2) summary

COG0514
Location:16 → 440

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:627 → 815

RecQ5; RecQ helicase protein-like 5 (RecQ5)
XM_036156366.1 → XP_036012259.1 ATP-dependent DNA helicase Q5 isoform X2

UniProtKB/Swiss-Prot

Q8BQD7, Q8C7T6, Q8VID3, Q8VID5

Conserved Domains (2) summary

COG0514
Location:15 → 439

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

pfam06959
Location:626 → 817

RecQ5; RecQ helicase protein-like 5 (RecQ5)
XM_006532363.5 → XP_006532426.1 ATP-dependent DNA helicase Q5 isoform X6

Conserved Domains (2) summary

pfam06959
Location:231 → 419

RecQ5; RecQ helicase protein-like 5 (RecQ5)

pfam16124
Location:17 → 40

RecQ_Zn_bind; RecQ zinc-binding
XM_006532362.4 → XP_006532425.1 ATP-dependent DNA helicase Q5 isoform X5

Conserved Domains (2) summary

pfam06959
Location:231 → 419

RecQ5; RecQ helicase protein-like 5 (RecQ5)

pfam16124
Location:12 → 40

RecQ_Zn_bind; RecQ zinc-binding
XM_030245614.2 → XP_030101474.1 ATP-dependent DNA helicase Q5 isoform X7

Conserved Domains (1) summary

COG0514
Location:16 → 440

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]