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    Manea mannosidase, endo-alpha [ Mus musculus (house mouse) ]

    Gene ID: 242362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maneaprovided by MGI
    Official Full Name
    mannosidase, endo-alphaprovided by MGI
    Primary source
    MGI:MGI:2444484
    See related
    Ensembl:ENSMUSG00000040520 AllianceGenome:MGI:2444484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932703L02Rik
    Summary
    Predicted to enable glycoprotein endo-alpha-1,2-mannosidase activity. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.9), cerebellum adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Manea in Genome Data Viewer
    Location:
    4 A3; 4 10.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (26324506..26346913, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (26324506..26346918, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hematological and neurological expressed 1 pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09794 Neighboring gene STARR-seq mESC enhancer starr_09795 Neighboring gene STARR-seq mESC enhancer starr_09796 Neighboring gene predicted gene, 24965 Neighboring gene STARR-seq mESC enhancer starr_09797 Neighboring gene STARR-seq mESC enhancer starr_09798 Neighboring gene STARR-seq mESC enhancer starr_09802 Neighboring gene STARR-positive B cell enhancer ABC_E7957 Neighboring gene STARR-positive B cell enhancer ABC_E10227 Neighboring gene STARR-seq mESC enhancer starr_09803 Neighboring gene betaine-homocysteine methyltransferase, pseudogene 1 Neighboring gene ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycoprotein endo-alpha-1,2-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycoprotein endo-alpha-1,2-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycoprotein endo-alpha-1,2-mannosidase
    Names
    endo-alpha mannosidase
    endomannosidase
    mEndo
    NP_001398666.1
    NP_001398675.1
    NP_766453.2
    XP_006537962.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411737.1 → NP_001398666.1  glycoprotein endo-alpha-1,2-mannosidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL805949

    2. NM_001411746.1 → NP_001398675.1  glycoprotein endo-alpha-1,2-mannosidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL805949

    3. NM_172865.3 → NP_766453.2  glycoprotein endo-alpha-1,2-mannosidase isoform 1

      See identical proteins and their annotated locations for NP_766453.2

      Status: VALIDATED

      Source sequence(s)
      AL805949
      Consensus CDS
      CCDS18012.1
      UniProtKB/Swiss-Prot
      Q6NXH2, Q8C0N9
      Related
      ENSMUSP00000038671.8, ENSMUST00000041374.8
      Conserved Domains (1) summary
      pfam16317
      Location:98 → 448
      Glyco_hydro_99; Glycosyl hydrolase family 99

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      26324506..26346913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537899.5 → XP_006537962.1  glycoprotein endo-alpha-1,2-mannosidase isoform X1

      See identical proteins and their annotated locations for XP_006537962.1

      UniProtKB/Swiss-Prot
      Q6NXH2, Q8C0N9
      Conserved Domains (1) summary
      pfam16317
      Location:98 → 448
      Glyco_hydro_99; Glycosyl hydrolase family 99
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXH2.1 GenPept UniProtKB/Swiss-Prot:Q6NXH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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