snf sans fille [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: snfprovided by FlyBase
Official Full Name: sans filleprovided by FlyBase
Primary source: FLYBASE:FBgn0003449
Locus tag: Dmel_CG4528
See related: AllianceGenome:FB:FBgn0003449
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4528; D25; Dmel\CG4528; dSNF; fs(1)1621; fs(1)A16121; fs(1)A1621; liz; Snf; SNF; SNF/D25; snf1621; snRNP B''; snRNP-U1-A; U1-A; U1A; U2 snRNP; U2 snRNP B'' protein; U2B
Summary: Enables RNA binding activity and identical protein binding activity. Involved in oogenesis and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Used to study germ cell cancer. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to several human genes including SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4F4-4F4; 1-11 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5309242..5310501)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5203275..5204534)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin.
Title: In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin.
Data show that SWI/SNF complexes play a role in the cleavage of specific pre-mRNAs in animal cells.
Title: SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3' end processing.
U2A' immobilizes SNF and RNA residues to restore U2 stem-loop IV binding affinity, while U1 stem-loop II binding does not require such adjustments. Study findings show how U2A' can modulate RNA specificity of SNF without changing SNF conformation or relying on direct RNA contacts.
Title: Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.
SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahma
Title: SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahma.
SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs.
Title: SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster.
SNR1 functions as a regulatory subunit to modulate chromatin remodeling activities of the Brahma complex on target genes, including both activation and repression
Title: Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
The binding mechanism of SNF changes depending on its RNA target; SNF's ability to bind Drosophila stem-loop (SL)IV along with its inability to bind human SLIV indicates that evolutionary adaptation has occurred in both the protein and the RNA.
Title: Coevolution of Drosophila snf protein and its snRNA targets.
SEX-LETHAL interacts with SANS-FILLE in the context of the U1 snRNP, through the characterization of a point mutation that interferes with both assembly into the U1 snRNP and complex formation with SEX-LETHAL.
Title: Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U1 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-mRNA intronic pyrimidine-rich binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables snRNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	TAS Traceable Author Statement more info	PubMed
involved_in female germ-line sex determination	NAS Non-traceable Author Statement more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary sex determination, soma	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of U1 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U1 snRNP	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of U2 snRNP	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of small nuclear ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of small nuclear ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sans fille

Names: CG4528-PA; Sans-fille; simply not fertile; snf-PA; splicing necessary factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5309242..5310501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078490.4 → NP_511045.1 sans fille [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P43332, Q9W4D7

Related

FBpp0070716

Conserved Domains (3) summary

COG0724
Location:5 → 177

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12479
Location:137 → 216

RRM2_SNF; RNA recognition motif 2 found in Drosophila melanogaster sex determination protein SNF and similar proteins

cl17169
Location:6 → 96

RRM_SF; RNA recognition motif (RRM) superfamily