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    PQBP1 Poly-glutamine tract binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PQBP1provided by FlyBase
    Official Full Name
    Poly-glutamine tract binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039270
    Locus tag
    Dmel_CG11820
    See related
    AllianceGenome:FB:FBgn0039270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11820; Dmel\CG11820; dPQBP-1; dpqbp1; dPQBP1; PQBP-1
    Summary
    Involved in several processes, including microvillus organization; olfactory learning; and rhabdomere development. Located in nucleus and rough endoplasmic reticulum. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; anterior endoderm; central brain primordium; embryonic/larval midgut primordium; and ganglia. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See PQBP1 in Genome Data Viewer
    Location:
    96B19-96B19; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25065791..25066718)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20891513..20892440)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene staccato Neighboring gene veli Neighboring gene Catalytic subunit 3B of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. Yoshimura N, et al. FEBS Lett, 2006 Apr 17. PMID 16597440
    2. A restricted level of PQBP1 is needed for the best longevity of Drosophila. Tamura T, et al. Neurobiol Aging, 2013 Jan. PMID 22901698
    3. Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Zhang XY, et al. Hum Mol Genet, 2017 Mar 1. PMID 28073926
    4. Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. Tamura T, et al. J Neurosci, 2010 Oct 20. PMID 20962230, Free PMC Article
    5. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in microvillus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Poly-glutamine tract binding protein 1
    Names
    CG11820-PA
    PQBP1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25065791..25066718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143074.4 → NP_651331.1  Poly-glutamine tract binding protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBY6
      Related
      FBpp0084140
      Conserved Domains (1) summary
      pfam00397
      Location:130 → 160
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBY6 Q9VBY6

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