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    Hacl 2-hydroxyacyl-CoA lyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Haclprovided by FlyBase
    Official Full Name
    2-hydroxyacyl-CoA lyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034488
    Locus tag
    Dmel_CG11208
    See related
    AllianceGenome:FB:FBgn0034488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.196; CG11208; Dmel\CG11208; HACL1
    Summary
    Predicted to enable 2-hydroxyacyl-CoA lyase activity and thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and mesoderm. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hacl in Genome Data Viewer
    Location:
    56F11-56F11; 2-90 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20242752..20245388, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16130257..16132893, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EF-hand domain containing 1.2 Neighboring gene pickpocket 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
    2. Sequencing mRNA from cryo-sliced Drosophila embryos to determine genome-wide spatial patterns of gene expression. Combs PA, et al. PLoS One, 2013. PMID 23951250, Free PMC Article
    3. Drosophila ventral furrow morphogenesis: a proteomic analysis. Gong L, et al. Development, 2004 Feb. PMID 14711877
    4. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article
    5. Absolute Quantification of Proteins in the Eye of Drosophila melanogaster. Raghuraman BK, et al. Proteomics, 2020 Dec. PMID 32663363

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-hydroxyacyl-CoA lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid alpha-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase
    Names
    2-hydroxyacyl-CoA lyase 1
    CG11208-PA
    Hacl-PA
    NP_611460.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20242752..20245388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137616.3 → NP_611460.1  2-hydroxyacyl-CoA lyase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3B7
      Related
      FBpp0085630
      Conserved Domains (4) summary
      cd07035
      Location:8 → 161
      TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
      PRK09259
      Location:8 → 552
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:367 → 550
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:195 → 322
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3B7 Q7K3B7

    Gene LinkOut

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