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    cdm cadmus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdmprovided by FlyBase
    Official Full Name
    cadmusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261532
    Locus tag
    Dmel_CG7212
    See related
    AllianceGenome:FB:FBgn0261532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3R23; Cdm; CG 7212; CG7212; Dmel\CG7212; imp13; Imp13; sd-5
    Summary
    Predicted to enable small GTPase binding activity. Involved in modulation of chemical synaptic transmission; neuron-neuron synaptic transmission; and phototaxis. Predicted to be active in cytoplasm. Is expressed in larval brain; larval somatic muscle cell; larval ventral nerve cord; organism; and spermatozoon. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cdm in Genome Data Viewer
    Location:
    90F5-90F5; 3-62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18179275..18183479, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14004997..14009201, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene cap binding protein 20 Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 5 Neighboring gene well-rounded Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy. Khalil B, et al. Mol Neurodegener, 2022 Dec 8. PMID 36482422, Free PMC Article
    2. Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. Bono F, et al. Mol Cell, 2010 Jan 29. PMID 20122403
    3. Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways. Kimura M, et al. Traffic, 2014 Jul. PMID 24766099
    4. Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster. Moazzen H, et al. Mech Dev, 2009 Aug-Sep. PMID 19563886
    5. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imp13 forms a ring-like molecule encircling the Mago-Y14 cargo with a conserved interaction surface.
      Title: Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13.
    2. Imp13 is a novel factor that affects neurotransmitter release at the fly neuromuscular junction.
      Title: Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cadmus
    Names
    CG7212-PA
    CG7212-PB
    cdm-PA
    cdm-PB
    complementation group 5
    importin 13
    importin-13
    sd-5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18179275..18183479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275767.1 → NP_001262696.1  cadmus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEC5
      Conserved Domains (4) summary
      smart00913
      Location:29 → 93
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98 → 217
      Xpo1; Exportin 1-like protein
      pfam18773
      Location:418 → 454
      Importin_rep; Importin 13 repeat
      pfam18806
      Location:838 → 912
      Importin_rep_3; Importin 13 repeat

    2. NM_142425.3 → NP_650682.1  cadmus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEC5
      Related
      FBpp0083039
      Conserved Domains (4) summary
      smart00913
      Location:29 → 93
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98 → 217
      Xpo1; Exportin 1-like protein
      pfam18773
      Location:418 → 454
      Importin_rep; Importin 13 repeat
      pfam18806
      Location:838 → 912
      Importin_rep_3; Importin 13 repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEC5 Q9VEC5

    Gene LinkOut

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