fz frizzled [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fzprovided by FlyBase
Official Full Name: frizzledprovided by FlyBase
Primary source: FLYBASE:FBgn0001085
Locus tag: Dmel_CG17697
See related: AllianceGenome:FB:FBgn0001085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17697; CG3646; dFz; Dfz; DFz; Dfz1; DFz1; DFZ1; Dm Fz1; Dmel\CG17697; Frizzled; frz; Frz; Fz; FZ; fz1; Fz1; FZ1; Fzd; fz[[1]]
Summary: Enables Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including neuron differentiation; positive regulation of cell projection organization; and regionalization. Located in plasma membrane. Colocalizes with endosome. Is expressed in several structures, including central nervous system; cuboidal/columnar epithelium; imaginal disc; nephrocyte; and organism subdivision. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to several human genes including FZD1 (frizzled class receptor 1) and FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70D4-70D5; 3-42 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14274343..14368639)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14267443..14361739)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The stabilizing function of Prickle on Frizzled requires Prickle activity in neighboring cells. Conversely, Prickle in the same cell has a destabilizing effect on Frizzled.
Title: A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity.
The transmembrane proteins Frizzled and Flamingo form a stoichiometric nucleus in the complex, while the relative levels of the other four core proteins can vary independently.we show that robust cell polarization is achieved over a range of complex stoichiometries but is dependent on maintaining appropriate levels of the components Frizzled and Strabismus.
Title: Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry.
instructive input of Frizzled-Planar cell polarity (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings, is reported.
Title: Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling.
Studies indicate that Frizzled (Fz) is constitutively ubiquitinated and internalized to the early endosome.
Title: Balanced ubiquitination determines cellular responsiveness to extracellular stimuli.
These data are the first to show that Netrin and Frazzled regulate the placement of gap junctions presynaptically at a synapse.
Title: Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
We found no evidence for an essential requirement of the Fz C-terminal tail downstream of the KTxxxW motif in planar polarity and canonical Wnt signaling.
Title: Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling.
Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2.
Title: The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2.
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
Title: Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
Frazzled is expressed and cell autonomously required in R8 photoreceptors for directing their axons to the medulla-neuropil layer M3.
Title: Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila.
Frizzled and Dishevelled are enriched at distal sides of each cell and hence localize at the interface with ligand-expressing cells in the non-responding cells.
Title: Planar cell polarity controls directional Notch signaling in the Drosophila leg.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R3/R4 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cardioblast cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chitin-based larval cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing hair site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midgut development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: frizzled

Names: CG17697-PA; CG17697-PC; Frizzled1; frizzed; frizzled 1; frizzled[[1]]; fz-PA; fz-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14274343..14368639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080073.3 → NP_524812.1 frizzled, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524812.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18537, Q9VUE0, Q9VUE2

Related

FBpp0075485

Conserved Domains (2) summary

cd07458
Location:51 → 167

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

pfam01534
Location:237 → 564

Frizzled; Frizzled/Smoothened family membrane region
NM_001274907.1 → NP_001261836.1 frizzled, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261836.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFL6

Conserved Domains (2) summary

cd07458
Location:51 → 167

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

pfam01534
Location:237 → 564

Frizzled; Frizzled/Smoothened family membrane region