tgo tango [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tgoprovided by FlyBase
Official Full Name: tangoprovided by FlyBase
Primary source: FLYBASE:FBgn0264075
Locus tag: Dmel_CG11987
See related: AllianceGenome:FB:FBgn0264075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: arnt; Arnt; ARNT; bHLHe4; CG11987; darnt; dARNT; DARNT; dHIF-1beta; Dmel\CG11987; dTgo; HIF-1; HIF-1b; HIF-1beta; Hif1; HIF1; HIF1b; HIF1B; HIF1B/ARNT; jay; prd7; Tango; Tgo; TGO; tgo/Arnt; TGO_CYC
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; myosin binding activity; and protein heterodimerization activity. Involved in several processes, including imaginal disc-derived leg joint morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including embryonic head segment; ganglia; glial cell; presumptive embryonic/larval system; and tracheal primordium. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator) and ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85C2-85C2; 3-48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9016773..9020022, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4842495..4845744, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation.
Title: The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation.
an upstream regulatory region of cv is directly responsive to the basic, helix-loop-helix-PAS domain factors Trachealess (Trh) and Tango (Tgo), that function to specify tracheal fate.
Title: Crossveinless is a direct transcriptional target of Trachealess and Tango in Drosophila tracheal precursor cells.
Maintenance of ER/Golgi architecture and bulky cargo transport are the primary functions for Tango1.
Title: Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology.
the Tango-Trace strategy we used may be applied more generally to identify neural circuits in the fly brain
Title: Identifying functional connections of the inner photoreceptors in Drosophila using Tango-Trace.
Study shows that jing is a direct downstream target of Trh/Tgo and that Vvl and Pnt are also involved in jing tracheal activation.
Title: The Drosophila jing gene is a downstream target in the Trachealess/Tango tracheal pathway.
Dysfusion dimerizes with the Tango bHLH-PAS protein, and together they act as a DNA binding transcriptional activator
Title: Transcriptional specificity of Drosophila dysfusion and the control of tracheal fusion cell gene expression.
These results together identify TGO's transactivation domain and establish its importance for proper target gene regulation and cellular specification.
Title: Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor.
HIF-1 control of heat shock factor transcriptional levels is a regulatory mechanism for sensitizing heat shock pathway activity in order to maximize production of protective heat shock proteins
Title: Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1.
trachealess and tango, both encoding bHLH-PAS proteins that are required for the formation of the embryonic tracheal system, are essential for forming two adjacent distal segments of the leg
Title: Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in appendage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tango

Names: CG11987-PA; CG11987-PB; PRD gene 7; jaywalker; paired-like 7; tgo-PA; tgo-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9016773..9020022 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169254.2 → NP_731308.1 tango, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731308.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15945, O16167, O44082, Q24461, Q9VHI2

UniProtKB/TrEMBL

A0A0B4KFJ2

Related

FBpp0081483

Conserved Domains (5) summary

smart00091
Location:90 → 154

PAS; PAS domain

cd00130
Location:283 → 380

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:15 → 67

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:87 → 192

PAS; PAS fold

pfam14598
Location:283 → 384

PAS_11; PAS domain
NM_001275468.1 → NP_001262397.1 tango, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262397.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O15945, O16167, O44082, Q24461, Q9VHI2

UniProtKB/TrEMBL

A0A0B4KFJ2

Conserved Domains (5) summary

smart00091
Location:90 → 154

PAS; PAS domain

cd00130
Location:283 → 380

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:15 → 67

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:87 → 192

PAS; PAS fold

pfam14598
Location:283 → 384

PAS_11; PAS domain