U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Srp54 Splicing regulatory protein 54 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34312, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Srp54provided by FlyBase
    Official Full Name
    Splicing regulatory protein 54provided by FlyBase
    Primary source
    FLYBASE:FBgn0024285
    Locus tag
    Dmel_CG4602
    See related
    AllianceGenome:FB:FBgn0024285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.16; CG4602; clone 2.16; Dmel\CG4602; dSRp54; p75; srp54; SRp54; SRP54
    Summary
    Enables mRNA binding activity and poly-pyrimidine tract binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including SRSF11 (serine and arginine rich splicing factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Srp54 in Genome Data Viewer
    Location:
    30E4-30E4; 2-37 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9912911..9915044)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9912911..9915044)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Etl1 Neighboring gene yippee interacting protein 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SRP54 mediates circadian rhythm-related, temperature-dependent gene expression in Drosophila. Li Y, et al. Genomics, 2022 Nov. PMID 36273743
    2. A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Kennedy CF, et al. Mol Cell Biol, 1998 Sep. PMID 9710626, Free PMC Article
    3. Deterministic splicing of Dscam2 is regulated by Muscleblind. Li JSS, et al. Sci Adv, 2019 Jan. PMID 30746474, Free PMC Article
    4. Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2. Robard C, et al. Biochem J, 2006 Nov 15. PMID 16834570, Free PMC Article
    5. The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. Bennick RA, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277943

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly-pyrimidine tract binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    splicing regulatory protein 54
    Names
    CG4602-PA
    Srp54-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9912911..9915044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057999.5 → NP_477347.1  splicing regulatory protein 54 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61646, Q9VL71
      Related
      FBpp0079471
      Conserved Domains (2) summary
      cd12259
      Location:9 → 85
      RRM_SRSF11_SREK1; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11), splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12260
      Location:160 → 242
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61646 O61646
    Q9VL71 Q9VL71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.