numb numb [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: numbprovided by FlyBase
Official Full Name: numbprovided by FlyBase
Primary source: FLYBASE:FBgn0002973
Locus tag: Dmel_CG3779
See related: AllianceGenome:FB:FBgn0002973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3779; d-numb; Dmel\CG3779; dNumb; l(2)03235; l(2)3235; l(2)s2201; N7-1; nb; Nb; Numb; NUMB; numbs
Summary: Enables Notch binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; negative regulation of macromolecule metabolic process; and neurogenesis. Located in cell cortex. Is expressed in several structures, including Malpighian tubule tip cell primordium; anlage in statu nascendi; epithelium; somatic precursor cell; and visceral mesoderm derivative. Used to study brain cancer. Orthologous to several human genes including NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 30B3-30B5; 2-35 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9437469..9464184)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9437469..9464184)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
Title: Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
Numb levels are upregulated to reinforce the bias of Notch signaling activation in the R3/R4 pair, two post-mitotic cells that are not specified by asymmetric cell division.
Title: Regulation of Numb during planar cell polarity establishment in the Drosophila eye.
condensed Numb and Pon complex has roles in phase transition during Drosophila neuroblast asymmetric division
Title: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain
Title: Inscuteable maintains type I neuroblast lineage identity via Numb/Notch signaling in the Drosophila larval brain.
Data suggest that Numb controls the balance between Notch receptor recycling and receptor targeting to late endosomes to regulate signaling output after asymmetric cell division in Drosophila neural progenitors.
Title: Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells.
The authors find that Numb is regulated in part through its asymmetric and symmetric distribution during stem cell divisions; however, its de novo synthesis is also required during the differentiation of the enteroendocrine cells.
Title: Intrinsic regulation of enteroendocrine fate by Numb.
Spdo is sorted toward late endosomes in a Numb-dependent manner.
Title: A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo.
Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
Title: Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor.
Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
Title: Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
Data show regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.
Title: Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0331 (e-PCR)
- UniSTS:2176

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule tip cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in enteroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal part of cell	TAS Traceable Author Statement more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: numb

Names: CG3779-PA; CG3779-PB; CG3779-PD; d-Numb; numb-PA; numb-PB; numb-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9437469..9464184

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164855.2 → NP_723460.1 numb, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723460.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16554

Related

FBpp0079419

Conserved Domains (2) summary

cd01268
Location:26 → 160

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:228 → 333

NumbF; NUMB domain
NM_001273362.1 → NP_001260291.1 numb, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260291.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8

UniProtKB/TrEMBL

M9PCN6

Conserved Domains (2) summary

cd01268
Location:67 → 201

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:269 → 374

NumbF; NUMB domain
NM_078799.3 → NP_523523.2 numb, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523523.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8

UniProtKB/TrEMBL

M9PCN6

Related

FBpp0079420

Conserved Domains (2) summary

cd01268
Location:67 → 201

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:269 → 374

NumbF; NUMB domain