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    Ate1 Arginyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ate1provided by FlyBase
    Official Full Name
    Arginyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0025720
    Locus tag
    Dmel_CG9204
    See related
    AllianceGenome:FB:FBgn0025720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ate; ate1; ATE1; CG9204; Dm-Ate1; Dmel\CG9204; l(2)k10809
    Summary
    Predicted to enable arginyl-tRNA--protein transferase activity. Involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to be active in cytoplasm. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ate1 in Genome Data Viewer
    Location:
    56F11-56F11; 2-90 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20254966..20257390, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16142471..16144895, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pickpocket 6 Neighboring gene uncharacterized protein Neighboring gene Hormone-sensitive lipase Neighboring gene Proliferating cell nuclear antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 1999 Jan. PMID 9858543, Free PMC Article
    2. The N-end rule and regulation of apoptosis. Varshavsky A. Nat Cell Biol, 2003 May. PMID 12724766
    3. A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis. Wang Z, et al. Elife, 2017 Dec 12. PMID 29231806, Free PMC Article
    4. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Ditzel M, et al. Nat Cell Biol, 2003 May. PMID 12692559
    5. Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier. Zülbahar S, et al. Development, 2018 Aug 13. PMID 30002129

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables arginyl-tRNA--protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginyl-tRNA--protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein arginylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arginyltransferase 1
    Names
    Ate1-PA
    Ate1-PB
    Ate1-PC
    Ate1-PD
    CG9204-PA
    CG9204-PB
    CG9204-PC
    CG9204-PD
    NP_001261101.1
    NP_477394.3
    NP_725939.2
    NP_725940.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20254966..20257390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058046.5 → NP_477394.3  arginyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477394.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96539
      Related
      FBpp0085626
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:248 → 387
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    2. NM_166380.3 → NP_725940.2  arginyltransferase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725940.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96539
      Related
      FBpp0089149
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:249 → 388
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    3. NM_166379.3 → NP_725939.2  arginyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725939.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96539, Q7KRL0, Q86PB1, Q8IH08, Q8N0R9, Q8T7L5, Q9V906, Q9V907
      Related
      FBpp0085627
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:255 → 394
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    4. NM_001274172.1 → NP_001261101.1  arginyltransferase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFD5
      Conserved Domains (2) summary
      pfam04376
      Location:14 → 85
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:256 → 395
      ATE_C; Arginine-tRNA-protein transferase, C terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFD5 A0A0B4KFD5
    O96539.3 O96539

    Gene LinkOut

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